ReviewNeuroscience and biobehavioral reviews2010
Early attachment-figure separation and increased risk for later depression: potential mediation by proinflammatory processes.
Review in Neuroscience and biobehavioral reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Early attachment disruption differentially enhances multiple signs of microglia activation in the prefrontal cortex, hippocampus, and preoptic area of periadolescent guinea pigs.Behavioural brain research · 2027Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Early Life Adversity, Microbiome, and Inflammatory Responses.Biomolecules · 2024Review
- Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Association of Prenatal Alcohol Exposure and Prenatal Maternal Depression with Offspring Low-Grade Inflammation in Early Adolescence.International journal of environmental research and public health · 2021Article
- Transcriptomic analyses of humans and mice provide insights into depression.Zoological research · 2020Article
- Plasma microRNA Array Analysis Identifies Overexpressed miR-19b-3p as a Biomarker of Bipolar Depression Distinguishing From Unipolar Depression.Frontiers in psychiatry · 2020Article
- Advances and Future Directions of Diagnosis and Management of Pediatric Abusive Head Trauma: A Review of the Literature.Frontiers in neurology · 2020Review
- Early Attachment Disruption, Inflammation, and Vulnerability for Depression in Rodent and Primate Models.Frontiers in behavioral neuroscience · 2018Article
- Effects of early-life adversity on immune function are mediated by prenatal environment: Role of prenatal alcohol exposure.Brain, behavior, and immunity · 2017Article
- Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing.Social neuroscience · 2017Article
- Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.Developmental cognitive neuroscience · 2015Article
- Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation.Physiology & behavior · 2015Article
- Maternal Deprivation of Lewis Rat Pups Increases the Severity of Experi-mental Periodontitis in Adulthood.The open dentistry journal · 2015Article
- Filial attachment and its disruption: insights from the guinea pig.Developmental psychobiology · 2014Review
- Review
- Inflammation and early-life abuse in women.American journal of preventive medicine · 2012Article
- Early maternal separation leads to down-regulation of cytokine gene expression.Metabolic brain disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Early maternal separation and other disruptions of attachment relations are known to increase risk for the later onset of depressive illness in vulnerable individuals. It is suggested here that sensitization involving proinflammatory processes may contribute to this effect. This argument is based on: (1) current notions of the role of proinflammatory cytokines in depressive illness; (2) evidence that proinflammatory cytokines mediate depressive-like behavior during separation in a rodent model of infant attachment; and (3) comparisons of the effects of early proinflammatory activation versus maternal separation on later proinflammatory activity and biobehavioral processes related to depression. The possible interaction of proinflammatory processes and corticotropin-releasing factor in the sensitization process is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.