ArticleBMC microbiology2010
Surviving within the amoebal exocyst: the Mycobacterium avium complex paradigm.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
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- Evidence of an environmental reservoir for emergentNew microbes and new infections · 2020Article
- Insights From the Genome Sequence ofFrontiers in microbiology · 2019Article
- Predators and nutrient availability favor protozoa-resisting bacteria in aquatic systems.Scientific reports · 2018Article
- Global Environmental Nontuberculous Mycobacteria and Their Contemporaneous Man-Made and Natural Niches.Frontiers in microbiology · 2018Review
- Survival of pathogenic Mycobacterium abscessus subsp. massiliense in Acanthamoeba castellanii.Research in microbiology · 2018Article
- Repertoire of free-living protozoa in contact lens solutions.BMC ophthalmology · 2016Article
- Protozoan Cysts Act as a Survival Niche and Protective Shelter for Foodborne Pathogenic Bacteria.Applied and environmental microbiology · 2015Article
- Yersinia pseudotuberculosis IP32953 survives and replicates in trophozoites and persists in cysts of Acanthamoeba castellanii.FEMS microbiology letters · 2015Article
- Characterization of Three Mycobacterium spp. with Potential Use in Bioremediation by Genome Sequencing and Comparative Genomics.Genome biology and evolution · 2015Article
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- Current and past strategies for bacterial culture in clinical microbiology.Clinical microbiology reviews · 2015Review
- Mechanisms associated with phagocytosis of Arcobacter butzleri by Acanthamoeba castellanii.Parasitology research · 2014Article
- Article
- Potential role of bacteria packaging by protozoa in the persistence and transmission of pathogenic bacteria.Frontiers in microbiology · 2014Article
- Cooccurrence of free-living amoebae and nontuberculous Mycobacteria in hospital water networks, and preferential growth of Mycobacterium avium in Acanthamoeba lenticulata.Applied and environmental microbiology · 2013Article
- Mycobacterium gilvum illustrates size-correlated relationships between mycobacteria and Acanthamoeba polyphaga.Applied and environmental microbiology · 2013Article
- Diversity of Mycobacterium avium subsp. hominissuis mycobacteria causing lymphadenitis, France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of environmental mycobacteria have been previously demonstrated to resist free-living amoeba with subsequent increased virulence and resistance to antibiotics and biocides. The Mycobacterium avium complex (MAC) comprises of environmental organisms that inhabit a wide variety of ecological niches and exhibit a significant degree of genetic variability. We herein studied the intra-ameobal location of all members of the MAC as model organisms for environmental mycobacteria.
resultsType strains for M. avium, Mycobacterium intracellulare, Mycobacterium chimaera, Mycobacterium colombiense, Mycobacterium arosiense, Mycobacterium marseillense, Mycobacterium timonense and Mycobacterium bouchedurhonense were co-cultivated with the free-living amoeba Acanthamoeba polyphaga strain Linc-AP1. Microscopic analyses demonstrated the engulfment and replication of mycobacteria into vacuoles of A. polyphaga trophozoites. Mycobacteria were further entrapped within amoebal cysts, and survived encystment as demonstrated by subculturing. Electron microscopy observations show that, three days after entrapment into A. polyphaga cysts, all MAC members typically resided within the exocyst.
conclusionsCombined with published data, these observations indicate that mycobacteria are unique among amoeba-resistant bacteria, in residing within the exocyst.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.