ArticleMolecular diagnosis & therapy2010
Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population.
Article in Molecular diagnosis & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The Niche of n-of-1 Trials in Precision Medicine for Weight Loss and Obesity Treatment: Back to the Future.Current nutrition reports · 2022Review
- Pharmacogenomics of Medication-Induced Weight Gain and Antiobesity Medications.Obesity (Silver Spring, Md.) · 2021Review
- Network analysis of the genomic basis of the placebo effect.JCI insight · 2017Article
- UCP2, a mitochondrial protein regulated at multiple levels.Cellular and molecular life sciences : CMLS · 2014Review
- Uncoupling protein 2 gene polymorphisms are associated with obesity.Cardiovascular diabetology · 2012Article
- Assessing gene-gene interactions in pharmacogenomics.Molecular diagnosis & therapy · 2012Review
- Drug treatment for obesity in the post-sibutramine era.Drug safety · 2011Article
- Predictors of weight loss and maintenance in patients treated with antiobesity drugs.Diabetes, metabolic syndrome and obesity : targets and therapy · 2011Article
- A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity.Clinical pharmacology : advances and applications · 2010Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSibutramine, a serotonin and norepinephrine reuptake inhibitor, is used as an anti-obesity drug. Several pharmacogenetic studies have shown correlations between sibutramine effects and genetic variants, such as the 825C/T (rs5443) single nucleotide polymorphism (SNP) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene.
objectiveIn this study, our goal was to investigate whether a common SNP, -866G/A (rs659366), in the uncoupling protein 2 (UCP2) gene could influence weight reduction and body composition under sibutramine therapy in an obese Taiwanese population.
methodsThe study included 131 obese patients, 44 in the placebo group and 87 in the sibutramine group. We assessed the measures of weight loss and body fat reduction at the end of a 12-week treatment period by analysis of covariance (ANCOVA) models using gender, baseline weight, and body fat percentage at baseline as covariates. RESULTS AND
conclusionBy comparing the placebo and sibutramine groups with ANCOVA, our data showed a strong effect of sibutramine on weight loss in the combined UCP2 -866 AA + GA genotype groups (p < 0.001). Similarly, a strong effect of sibutramine on body fat percentage loss was found for individuals with the AA or GA genotypes (p < 0.001). In contrast, sibutramine had no significant effect on weight loss (p = 0.063) or body fat percentage loss (p = 0.194) for individuals with the wild-type GG genotype, compared with the placebo group of the same genotype. Moreover, a potential gene-gene interaction between UCP2 and GNB3 was identified by multiple linear regression models for the weight loss (p < 0.001) and for the percent fat loss (p = 0.031) in response to sibutramine. The results suggest that the UCP2 gene may contribute to weight loss and fat change in response to sibutramine therapy in obese Taiwanese patients.
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