ReviewJournal of physiology and biochemistry2009
Adipose tissue lymphocytes: types and roles.
Review in Journal of physiology and biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03260452 (Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers: Proof of Concept Study. White Adipose Tissue and Type 2 Diabetes Onset: WAT2DO
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early-Stage Lung Cancer.Journal of cachexia, sarcopenia and muscle · 2025Article
- Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair.Bioengineering (Basel, Switzerland) · 2024Review
- Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism.Frontiers in physiology · 2023Review
- Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.Obesity (Silver Spring, Md.) · 2022Article
- Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications.Frontiers in immunology · 2022Review
- Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.Scientific reports · 2021Article
- Review
- Sickness-Associated Anorexia: Mother Nature's Idea of Immunonutrition?Mediators of inflammation · 2016Review
- The cell biology of fat expansion.The Journal of cell biology · 2015Review
- Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes.Diabetes care · 2015Article
- Six weeks of voluntary wheel running modulates inflammatory protein (MCP-1, IL-6, and IL-10) and DAMP (Hsp72) responses to acute stress in white adipose tissue of lean rats.Brain, behavior, and immunity · 2014Article
- What the genetics of lipodystrophy can teach us about insulin resistance and diabetes.Current diabetes reports · 2013Review
- Cellular heterogeneity in superficial and deep subcutaneous adipose tissues in overweight patients.Journal of physiology and biochemistry · 2013Article
- Neuroimmune communication in hypertension and obesity: a new therapeutic angle?Pharmacology & therapeutics · 2013Review
- Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity.European journal of medical research · 2013Review
- The immunobiology of the mammalian epididymis: the black box is now open!Basic and clinical andrology · 2013Article
- Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.PloS one · 2013Article
- Adaptive immunity in obesity and insulin resistance.Nature reviews. Endocrinology · 2012Review
- The inflammation highway: metabolism accelerates inflammatory traffic in obesity.Immunological reviews · 2012Review
Corrections and comments
- Erratum issuedCastiella, L [corrected to Casteilla, L]
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides adipocytes, specialized in lipid handling and involved in energy balance regulation, white adipose tissue (WAT) is mainly composed of other cell types among which lymphocytes represent a non-negligible proportion. Different types of lymphocytes (B, alphabetaT, gammadeltaT, NK and NKT) have been detected in WAT of rodents or humans, and vary in their relative proportion according to the fat pad anatomical location. The lymphocytes found in intra-abdominal, visceral fat pads seem representative of innate immunity, while those present in subcutaneous fat depots are part of adaptive immunity, at least in mice. Both the number and the activity of the different lymphocyte classes, except B lymphocytes, are modified in obesity. Several of these modifications in the relative proportions of the lymphocyte classes depend on the degree of obesity, or on leptin concentration, or even fat depot anatomical location. Recent studies suggest that alterations of lymphocyte number and composition precede the macrophage increase and the enhanced inflammatory state of WAT found in obesity. Lymphocytes express receptors to adipokines while several proinflammatory chemokines are produced in WAT, rendering intricate crosstalk between fat and immune cells. However, the evidences and controversies available so far are in favour of an involvement of lymphocytes in the control of the number of other cells in WAT, either adipocytes or immune cells and of their secretory and metabolic activities. Therefore, immunotherapy deserves to be considered as a promising approach to treat the endocrino-metabolic disorders associated to excessive fat mass development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.