ArticleMolecular biology reports2011
ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.Journal of clinical laboratory analysis · 2020Pooled it
- RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21,236 cases and 19,407 controls.Scientific reports · 2015Pooled it
- MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis.Molecular biology reports · 2011Pooled it
- An association between the -41657 C/T polymorphism of X-ray repair cross-complementing 2 (XRCC2) gene and ovarian cancer.Medical oncology (Northwood, London, England) · 2014Trial
- The Role and Antagonistic Effects of miR-16-5p in the Regulation of ADP-Ribosylation Factor-Like Tumor Suppressor Gene 1 in Lung Cancer Cells.The Eurasian journal of medicine · 2023Article
- Elevated Expression of theCancers · 2021Article
- Diabetic Pneumopathy-A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations.Frontiers in endocrinology · 2021Review
- ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling.The Journal of biological chemistry · 2018Article
- Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Lack of an Association between a Functional Polymorphism in theReports of biochemistry & molecular biology · 2017Article
- Review
- Mosaic 13q14 deletions in peripheral leukocytes of non-hematologic cancer cases and healthy controls.Journal of human genetics · 2016Article
- Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population.Archives of gynecology and obstetrics · 2014Article
- Co-expression of Oct-4 and Nestin in human breast cancers.Molecular biology reports · 2012Article
- Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population.Molecular biology reports · 2012Article
- Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.Molecular biology reports · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic factors that contribute to the risk of breast cancer are largely not known and association studies have revealed several genes with low penetrance risk alleles for breast cancer. Analysis of these genes may provide important information on the risk factors affecting carcinogenesis. Variations in the ARLTS1, RAD51 and MDM2 genes have been associated with increased risk of different cancer types but for breast cancer the results are not consistent. In this study we investigated the role of the allelic variants in candidate genes acting in the tumor suppressor, DNA repair and p53 pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease. Presence of the polymorphic variants were investigated by amplification of the corresponding regions and restriction fragment length polymorphism analysis. Genotype and allele frequencies in the patients were significantly different for all three variants. Our results indicate that the polymorphic variants might affect individual susceptibility towards breast cancer.
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