ArticleInfection2010
An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients.
Article in Infection, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Burkholderia cepacia complex bacteremia: an outbreak investigation with epidemiological link to contaminated disinfectant.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Optimizing neutralization strategies for microbial testing of non-sterile pharmaceutical finished products with challenging method suitability.BMC microbiology · 2025Article
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- Comparative microbiome profiling reveals unique signatures in multiple primary lung cancers.Translational cancer research · 2025Article
- Colony morphotype variation inJournal of bacteriology · 2025Review
- Dynamics understanding of novel solvated drug molecules against emergingResults in chemistry · 2025Article
- Catheter-related bloodstream infection caused byGerms · 2022Article
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- Outbreak of Burkholderia Cepacia Infection: a Systematic Study in a Hematolooncology Unit of a Tertiary Care Hospital from Eastern India.Mediterranean journal of hematology and infectious diseases · 2018Article
- Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented byJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Cell Wall Recycling-Linked Coregulation of AmpC and PenB β-Lactamases through ampD Mutations in Burkholderia cenocepacia.Antimicrobial agents and chemotherapy · 2015Article
- Epidemiology of infections in cancer patients.Cancer treatment and research · 2014Review
- Emergence of Burkholderia cepacia in Honolulu: a case of nursing home-acquired B. cepacia sepsis.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2013Article
- Combining functional and structural genomics to sample the essential Burkholderia structome.PloS one · 2013Article
- Burkholderia vaccines: are we moving forward?Frontiers in cellular and infection microbiology · 2013Review
- Burkholderia cenocepacia bacteremia without respiratory colonization in an adult intensive care unit: epidemiological and molecular investigation of an outbreak.Hippokratia · 2012Article
- A rare case of community acquired Burkholderia cepacia infection presenting as pyopneumothorax in an immunocompetent individual.Asian Pacific journal of tropical biomedicine · 2012Article
- The use of nanoscale visible light-responsive photocatalyst TiO2-Pt for the elimination of soil-borne pathogens.PloS one · 2012Article
- Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.BMC systems biology · 2011Article
- A case of native valve endocarditis caused by Burkholderia cepacia without predisposing factors.BMC infectious diseases · 2011Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurkholderia cepacia is a common environmental bacterium that is resistant to disinfectants, and therefore is often encountered as a hospital-acquired pathogen. We describe an outbreak of B. cenocepacia bacteremia among hospitalized oncology patients.
methodsA matched case-control study and an extensive environmental investigation were conducted. Species were identified by RFLP of the amplified recA gene. DNA was fingerprinted by pulsed-field gel electrophoresis (PFGE).
resultsBetween November 2005 and September 2006, B. cenocepacia bacteremia developed in 17 patients with underlying malignancy of whom 14 had tunneled central venous catheters. All patients had fever and chills which subsided following removal of the central catheter and administration of ceftazidime. Extensive epidemiological investigation could not find a common source for the outbreak. Patients were hospitalized in three different buildings with different health care personnel. Medications were prepared in different sites by different personnel. A multivariate analysis demonstrated that the independent risk factors for developing nosocomial B. cenocepacia bacteremia were hospitalization at the center for long-term support (OR 28.8; 95% CI 1.83-453.4) and reduced use of antibiotics during the last month (OR 0.07; 95% CI 0.01-0.40). All isolates had identical antimicrobial susceptibility; PFGE indicated that a complex of closely related strains was involved in the outbreak. All isolates were identified as B. cenocepacia, known to infect cystic fibrosis patients. Strict infection control measures terminated the outbreak.
conclusionsB. cenocepacia is an emerging nosocomial pathogen among oncology patients.
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