ArticleMicrofluidics and nanofluidics2009
Surface molecular property modifications for poly(dimethylsiloxane) (PDMS) based microfluidic devices.
Article in Microfluidics and nanofluidics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed.
- Perspective on 3D microfluidic eye-on-a-chip technology for ophthalmological research.European biophysics journal : EBJ · 2026Review
- Reducing Small Molecule Adsorption in a PDMS-Based Microphysiological System of the Female Reproductive Tract via Parylene-C Coating to Improve Mechanistic Studies.ACS applied materials & interfaces · 2026Article
- Experimental study on the influence of PDA-modified PDMS on the biological behavior of mouse fibroblasts.Scientific reports · 2026Article
- Microfluidic Approaches to Pickering Emulsions and Foams: Strategies, Challenges, and Promising Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- hESCs-derived Organoids Achieve Liver Zonation Features through LSEC Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Understanding the Stability of Poorly Covered Pickering Emulsions Using on-Chip Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Thorough Review of Emerging Technologies in Micro- and Nanochannel Fabrication: Limitations, Applications, and Comparison.Micromachines · 2024Review
- A deployable film method to enable replicable sampling of low-abundance environmental microbiomes.Scientific reports · 2024Article
- Separators and Membranes for Advanced Alkaline Water Electrolysis.Chemical reviews · 2024Review
- Liquid plug propagation in computer-controlled microfluidic airway-on-a-chip with semi-circular microchannels.Lab on a chip · 2024Article
- An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery.Biomaterials research · 2024Article
- Microfluidic models of the neurovascular unit: a translational view.Fluids and barriers of the CNS · 2023Review
- Aryl-diazonium salts offer a rapid and cost-efficient method to functionalize plastic microfluidic devices for increased immunoaffinity capture.Advanced materials technologies · 2023Article
- Proteomics Methodologies: The Search of Protein Biomarkers Using Microfluidic Systems Coupled to Mass Spectrometry.Proteomes · 2023Review
- Easy-to-Build and Reusable Microfluidic Device for the Dynamic Culture of Human Bronchial Cystic Fibrosis Epithelia.ACS biomaterials science & engineering · 2023Article
- Optically driven microtools with an antibody-immobilised surface for on-site cell assembly.IET nanobiotechnology · 2023Article
- Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease.Communications biology · 2023Article
- Microfluidic delivery of cutting enzymes for fragmentation of surface-adsorbed DNA molecules.PloS one · 2023Article
- Challenge of material haemocompatibility for microfluidic blood-contacting applications.Frontiers in bioengineering and biotechnology · 2023Review
- Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation.Bioengineering (Basel, Switzerland) · 2022Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Fast advancements of microfabrication processes in past two decades have reached to a fairly matured stage that we can manufacture a wide range of microfluidic devices. At present, the main challenge is the control of nanoscale properties on the surface of lab-on-a-chip to satisfy the need for biomedical applications. For example, poly(dimethylsiloxane) (PDMS) is a commonly used material for microfluidic circuitry, yet the hydrophobic nature of PDMS surface suffers serious nonspecific protein adsorption. Thus the current major efforts are focused on surface molecular property treatments for satisfying specific needs in handling macro functional molecules. Reviewing surface modifications of all types of materials used in microfluidics will be too broad. This review will only summarize recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology and classify them into two main categories: (1) physical approach including physisorption of charged or amphiphilic polymers and copolymers, as well as (2) chemical approach including self assembled monolayer and thick polymer coating. Pros and cons of a collection of available yet fully exploited surface modification methods are briefly compared among subcategories.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.