ArticleHFSP journal2009
Integrating ELF4 into the circadian system through combined structural and functional studies.
Article in HFSP journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 108 citations in OpenAlex.
- The circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress.Npj biological timing and sleep · 2025Article
- Early Flowering 3 (ELF3) Inhibits Hypocotyl Phototropism in Light-GrownPlant direct · 2025Article
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- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- Whole-genome identification ofFrontiers in plant science · 2025Article
- Dual roles of pear EARLY FLOWERING 4 -like genes in regulating flowering and leaf senescence.BMC plant biology · 2024Article
- Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.Genetics · 2024Article
- Wheat EARLY FLOWERING 3 affects heading date without disrupting circadian oscillations.Plant physiology · 2023Article
- Limited water stress modulates expression of circadian clock genes in Brachypodium distachyon roots.Scientific reports · 2023Article
- Chromosome-scale assembly and annotation of the perennial ryegrass genome.BMC genomics · 2022Article
- LUX ARRHYTHMO Interacts With ELF3a and ELF4a to Coordinate Vegetative Growth and Photoperiodic Flowering in Rice.Frontiers in plant science · 2022Article
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- Genome-Wide Identification of theFrontiers in genetics · 2021Article
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- Interspecific analysis of diurnal gene regulation in panicoid grasses identifies known and novel regulatory motifs.BMC genomics · 2020Article
- Differential Effects of Day/Night Cues and the Circadian Clock on the Barley Transcriptome.Plant physiology · 2020Article
- A mobile ELF4 delivers circadian temperature information from shoots to roots.Nature plants · 2020Article
- Subcellular Localization of GIGANTEA Regulates the Timing of Leaf Senescence and Flowering inFrontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 5 countries.
Funding
Abstract
The circadian clock is a timekeeping mechanism that enables anticipation of daily environmental changes. In the plant Arabidopsis thaliana, the circadian system is a multiloop series of interlocked transcription-translation feedbacks. Several genes have been arranged in these oscillation loops, but the position of the core-clock gene ELF4 in this network was previously undetermined. ELF4 lacks sequence similarity to known domains, and functional homologs have not yet been identified. Here we show that ELF4 is functionally conserved within a subclade of related sequences, and forms an alpha-helical homodimer with a likely electrostatic interface that could be structurally modeled. We support this hypothesis by expression analysis of new elf4 hypomorphic alleles. These weak mutants were found to have expression level phenotypes of both morning and evening clock genes, implicating multiple entry points of ELF4 within the multiloop network. This could be mathematically modeled. Furthermore, morning-expression defects were particular to some elf4 alleles, suggesting predominant ELF4 action just preceding dawn. We provide a new hypothesis about ELF4 in the oscillator-it acts as a homodimer to integrate two arms of the circadian clock.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.