ArticlePlant physiology2010
Arabidopsis RAP2.2: an ethylene response transcription factor that is important for hypoxia survival.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.
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159 citing papers in PubMed, 375 citations in OpenAlex.
- Genome-wide identification and evolutionary analysis of the ERF-VII gene family in the tea plant (Camellia sinensis) and functional characterization of CsRAP2.2 in response to cold stress.Plant cell reports · 2026Article
- Genome-Wide Identification of AP2/ERF Transcription Factors inPlants (Basel, Switzerland) · 2026Article
- Elongator complex differentially regulates transcription and translation in the hypocotyl and cotyledons during early light-dependent Arabidopsis development.Plant & cell physiology · 2026Article
- Cross-Regulation of Metabolic and Immune Pathways in Plants Under Hypoxic Conditions.Plants (Basel, Switzerland) · 2026Review
- Discrete and cell-specific hypoxic responses in Arabidopsis roots resolved by single-nuclei transcriptomics.The New phytologist · 2026Article
- Plastid-to-nucleus communication under hypoxia involves group VII ethylene response factors inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-wide identification and characterization of SET domain family genes in Neopyropia yezoensis.BMC genomics · 2026Article
- ERF3 ofFrontiers in plant science · 2026Article
- Interaction Between CsATG8f and CsRAP2.12 Modulates Antioxidant Defense and Hypoxia Response During Submergence inInternational journal of molecular sciences · 2025Article
- Roles of ROS and NO in Plant Responses to Individual and Combined Salt Stress and Waterlogging.Antioxidants (Basel, Switzerland) · 2025Review
- An Ethylene-Response Factor LlERF092 Coordinates With LlETO1 to Improve Thermotolerance by Activating LlMBF1c in Lily.Plant biotechnology journal · 2025Article
- Genome-wide analysis of the AP2/ERF transcription factor superfamily in perennial ryegrass.BMC genomics · 2025Article
- Time-Series Elemental Imaging Reveals CAX-Dependent Redistribution Patterns for Anoxia Recovery.Journal of experimental botany · 2025Article
- Transfer RNA Aspartic Acid Methyltransferase 1 (TRDMT1/DNMT2) Regulates Plant Development and Gene Expression in the Moss Physcomitrium patens.Molecular genetics and genomics : MGG · 2025Article
- The AP2/ERF Gene Family in Camphor Tree: Structure, Evolution, and Transcriptional Response to Epicoccum Infection.Plants (Basel, Switzerland) · 2025Article
- Decoding plant responses to waterlogging: from stress signals to molecular mechanisms and their future implications.Plant molecular biology · 2025Review
- Article
- Identification of Candidate Genes for Hypoxia Tolerance in Rice by Genome-Wide Association Analysis and Transcriptome Sequencing.Rice (New York, N.Y.) · 2025Article
- Article
- Reciprocal modulation of responses to nitrate starvation and hypoxia in roots and leaves ofPlant signaling & behavior · 2024Article
99 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis (Arabidopsis thaliana) RAP2.2 (At3g14230) is an APETALA2/ethylene response factor-type transcription factor that belongs to the same subfamily as the rice (Oryza sativa) submergence tolerance gene SUB1A. RAP2.2 is expressed at constitutively high levels in the roots and at lower levels in the shoots, where it is induced by darkness. Effector studies and analysis of ethylene signal transduction mutants indicate that RAP2.2 is induced in shoots by ethylene and functions in an ethylene-controlled signal transduction pathway. Overexpression of RAP2.2 resulted in improved plant survival under hypoxia (low-oxygen) stress, whereas lines containing T-DNA knockouts of the gene had poorer survival rates than the wild type. This indicates that RAP2.2 is important in a plant's ability to resist hypoxia stress. Observation of the expression pattern of 32 low-oxygen and ethylene-associated genes showed that RAP2.2 affects only part of the low-oxygen response, particularly the induction of genes encoding sugar metabolism and fermentation pathway enzymes, as well as ethylene biosynthesis genes. Our results provide a new insight on the regulation of gene expression under low-oxygen conditions. Lighting plays an important regulatory role and is intertwined with hypoxia conditions; both stimuli may act collaboratively to regulate the hypoxic response.
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