ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study.Mediators of inflammation · 2018Trial
- IL-15 receptor alpha deficiency triggers depressive-like behaviors via enhanced microglial synapse pruning.Molecular psychiatry · 2026Article
- Neuronal correlates of spatial memory updating: c-Fos and GAD67 expression in the object-place recognition task.Scientific reports · 2026Article
- Single-cell transcriptome of mouse hippocampus identifies neural precursor-like cells, and reveals IL15Rα knock out-mediated neuron remodeling.BMC genomics · 2025Article
- Immune control of brain physiology.Nature reviews. Immunology · 2025Review
- Article
- Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodents.Frontiers in immunology · 2025Review
- Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour.Brain, behavior, & immunity - health · 2022Article
- Reduced Serum Levels of Soluble Interleukin-15 Receptor α in Schizophrenia and Its Relationship to the Excited Phenotype.Frontiers in psychiatry · 2022Article
- Blood cytokines differentiate bipolar disorder and major depressive disorder during a major depressive episode: Initial discovery and independent sample replication.Brain, behavior, & immunity - health · 2021Article
- Phenotypic Resemblance to Neuropsychiatric Disorder and Altered mRNA Profiles in Cortex and Hippocampus UnderlyingFrontiers in neuroscience · 2020Article
- Identification of Relationships Between Interleukin 15 mRNA and Brain-Derived Neurotrophic Factor II mRNA Levels With Formal Components of Temperament in Asthmatic Patients.Molecular neurobiology · 2017Article
- Identification of Novel Signal Transduction, Immune Function, and Oxidative Stress Genes and Pathways by Topiramate for Treatment of Methamphetamine Dependence Based on Secondary Outcomes.Frontiers in psychiatry · 2017Article
- Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system.Frontiers in microbiology · 2015Article
- Brain interleukin-15 in neuroinflammation and behavior.Neuroscience and biobehavioral reviews · 2013Review
- Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells.Molecular biology of the cell · 2011Article
- Potential protective role of IL15Rα during inflammation.Journal of molecular neuroscience : MN · 2011Article
- Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.Psychoneuroendocrinology · 2011Article
- Rapid endocytosis of interleukin-15 by cerebral endothelia.Journal of neurochemistry · 2011Article
- The effects of IL2Rgamma knockout on depression and contextual memory.Behavioural brain research · 2010Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin-15 (IL15) is a cytokine produced by normal brain, but the functions of the IL15 system in normal adults are not yet clear. The hypothesis that the hippocampal IL15 system is essential for memory consolidation was tested by use of IL15Ralpha knock-out mice in behavioral, biochemical, immunohistological, and electron microscopic analyses. The knock-out mice showed deficits in memory, determined by the Stone T-maze and fear conditioning. In their hippocampi, the concentration of GABA was significantly lower. There were region-specific changes of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD), with increased GAD-67-immunopositive interneurons in the stratum oriens of the CA1 region of the hippocampus, accompanied by nonsignificant reduction of GAD-67 synapses in the CA3 region. Western blotting showed an increase of GAD-65, but not GAD-67, in the hippocampal homogenate. The ultrastructure of the hippocampus remained intact in the knock-out mice. To further test the hypothesis that IL15 directly modulates GABA turnover by reuptake mechanisms, the dose-response relationship of IL15 on (3)H-GABA uptake was determined in two neuronal cell lines. The effective and nontoxic dose was further used in the synaptosomal uptake studies. IL15 decreased the uptake of (3)H-GABA in synaptosomes from the forebrain of wild-type mice. Consistent with this, IL15Ralpha knock-out mice had increased synaptosomal uptake of (3)H-GABA. Overall, the results show novel functions of a unique cytokine in normal hippocampal activity by regulating GABA transmission.
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