ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.Nature communications · 2026Article
- Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review.International journal of molecular sciences · 2020Review
- In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.International journal of molecular sciences · 2019Article
- A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination.Glia · 2019Article
- HSP90 is a chaperone for DLK and is required for axon injury signaling.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency.ACS medicinal chemistry letters · 2018Article
- The Dorsal Column Lesion Model of Spinal Cord Injury and Its Use in Deciphering the Neuron-Intrinsic Injury Response.Developmental neurobiology · 2018Review
- Review
- Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies.Frontiers in neuroscience · 2018Review
- GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients.JCI insight · 2017Article
- Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury.Neurobiology of disease · 2017Article
- In vitro models of axon regeneration.Experimental neurology · 2017Review
- Editorial: Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future.Frontiers in molecular neuroscience · 2017Article
- Screening out irrelevant cell-based models of disease.Nature reviews. Drug discovery · 2016Review
- Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow.Molecular brain · 2016Article
- Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- An in vitro assay to study induction of the regenerative state in sensory neurons.Experimental neurology · 2015Article
- Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.Journal of neuroinflammation · 2014Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
Abstract
A major barrier to regeneration of CNS axons is the presence of growth-inhibitory proteins associated with myelin and the glial scar. To identify chemical compounds with the ability to overcome the inhibition of regeneration, we screened a novel triazine library, based on the ability of compounds to increase neurite outgrowth from cerebellar neurons on inhibitory myelin substrates. The screen produced four "hit compounds," which act with nanomolar potency on several different neuronal types and on several distinct substrates relevant to glial inhibition. Moreover, the compounds selectively overcome inhibition rather than promote growth in general. The compounds do not affect neuronal cAMP levels, PKC activity, or EGFR (epidermal growth factor receptor) activation. Interestingly, one of the compounds alters microtubule dynamics and increases microtubule density in both fibroblasts and neurons. This same compound promotes regeneration of dorsal column axons after acute lesions and potentiates regeneration of optic nerve axons after nerve crush in vivo. These compounds should provide insight into the mechanisms through which glial-derived inhibitors of regeneration act, and could lead to the development of novel therapies for CNS injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.