ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Emergence of task-related spatiotemporal population dynamics in transplanted neurons.Nature communications · 2023Article
- Article
- Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.Communications biology · 2021Article
- Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD).Molecular autism · 2020Article
- Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports · 2019Review
- Human Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brain.Stem cell reports · 2019Article
- The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons.Cell reports · 2018Article
- Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells.Stem cells international · 2018Article
- Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells.Stem cell reports · 2017Article
- Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.Scientific reports · 2017Article
- Cell-based therapies for the treatment of schizophrenia.Brain research · 2017Review
- Article
- Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons.Cell stem cell · 2016Article
- Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer's and Parkinson's diseases.Brain research · 2016Review
- GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges.Neuroscience and biobehavioral reviews · 2016Review
- An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain.Scientific reports · 2016Article
- Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells.Development (Cambridge, England) · 2015Article
- Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives.Experimental & molecular medicine · 2015Review
- Reprogramming patient-derived cells to study the epilepsies.Nature neuroscience · 2015Review
- Interneurons from embryonic development to cell-based therapy.Science (New York, N.Y.) · 2014Review
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Authors and funding
5 authors.
Funding
Abstract
Despite their therapeutic potential, progress in generating fully differentiated forebrain neurons from embryonic stem cells (ESCs) has lagged behind that from more caudal regions of the neuraxis. GABAergic interneuron precursors have the remarkable ability to migrate extensively and survive after transplantation into postnatal cortex, making them an attractive candidate for use in cell-based therapy for seizures or other neuropsychiatric disorders. We have modified a mouse ESC line with an Lhx6-GFP reporter construct that allows for the isolation of newly generated cortical interneuron precursors. When transplanted into postnatal cortex, these cells can migrate into the cortical parenchyma, survive for months, and display morphological, neurochemical, and electrophysiological properties characteristic of mature interneurons. This work demonstrates that forebrain neuronal subtypes with complex traits can be generated from embryonic stem cells, and provides a novel approach to the study of cortical interneuron development and to the establishment of cell-based therapies for neurological disease.
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Registered trials
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