ArticleJournal of neurophysiology2010
Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Hypoxia releases S-nitrosocysteine from carotid body glomus cells-relevance to expression of the hypoxic ventilatory response.Frontiers in pharmacology · 2023Article
- A Methodological Perspective on the Function and Assessment of Peripheral Chemoreceptors in Heart Failure: A Review of Data from Clinical Trials.Biomolecules · 2022Review
- Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats.Frontiers in pharmacology · 2021Article
- Evaluation of Breath-Holding Test in Assessment of Peripheral Chemoreflex Sensitivity in Patients with Chronic Heart Failure.The open respiratory medicine journal · 2017Article
- Characterisation and comparison of temporal release profiles of nitric oxide generating donors.Journal of neuroscience methods · 2015Article
- Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.Physiology (Bethesda, Md.) · 2014Review
- Revisiting cAMP signaling in the carotid body.Frontiers in physiology · 2014Review
- Angiotensin peptides and nitric oxide in cardiovascular disease.Antioxidants & redox signaling · 2013Review
- Role of the carotid body in the pathophysiology of heart failure.Current hypertension reports · 2013Review
- Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability.The Journal of physiology · 2012Article
- Neurohumoral stimulation.Heart failure clinics · 2012Review
- Ventilatory behavior and carotid body morphology of Brown Norway and Sprague Dawley rats.Respiratory physiology & neurobiology · 2011Article
- Morphological differences of the carotid body among C57/BL6 (B6), A/J, and CSS B6A1 mouse strains.Respiratory physiology & neurobiology · 2011Article
- Angiotensin and carotid body chemoreception in heart failure.Current opinion in pharmacology · 2011Review
- Role of blood flow in carotid body chemoreflex function in heart failure.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Our previous studies show that a decrease in endogenous nitric oxide (NO) is involved in the blunted outward K(+) currents in carotid body (CB) glomus cells from chronic heart failure (CHF) rabbits. In the present study, we measured the effects of the neuronal nitric oxide synthase (nNOS) transgene on the K(+) currents in CB glomus cells from pacing-induced CHF rabbits. Using single-cell real-time RT-PCR and immunofluorescent techniques, we found that nNOS mRNA and protein are expressed in the rabbit CB glomus cells and CHF decreased the expression of nNOS mRNA and protein in CB glomus cells. After 3 days of an adenoviral nNOS (Ad.nNOS) gene transfection, the expression of nNOS protein was increased to the level found in sham CB glomus cells. In whole cell patch-clamp experiments, Ad.nNOS markedly reversed the attenuated K(+) currents in CB glomus cells from CHF rabbits. The specific nNOS inhibitor (S-methyl-l-thiocitrulline [SMTC]) and large-conductance Ca(2+)-activated K(+) (BK) channel blocker (iberiotoxin) fully abolished the effect of Ad.nNOS on the K(+) currents in the CB glomus cells from CHF rabbits. However, neither CHF nor Ad.nNOS altered the protein expression of BK channel alpha-subunit. These results suggest that a decrease of NO induced by an attenuated nNOS activity lowers the activation of the BK channels but not the protein expression of the BK channel alpha-subunit in the CB glomus cells during CHF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.