ArticleThe American journal of clinical nutrition2010
Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00069797 (Epidemiology of Coronary Heart Disease in Men Aged 40 and Over), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Coronary Heart Disease in Men Aged 40 and Over
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review.The British journal of nutrition · 2024Pooled it
- Associations of Serum Fatty Acids and the Eicosapentaenoic Acid/Arachidonic Acid Ratio with Hypertriglyceridemia in a Japanese Population: A Cross-Sectional Study.Journal of atherosclerosis and thrombosis · 2026Article
- Quantity of fat consumed predisposes cardiac tissues to greater metabolic risk than their level of saturation.Scientific reports · 2025Article
- Research on the mechanism of the anti-myocardial infarction effect of the Qiliqiangxin capsule on heart failure rats via nontargeted metabolomics and lipidomics.BMC cardiovascular disorders · 2024Article
- Effect ofMetabolites · 2021Article
- The effects of fat consumption on low-density lipoprotein particle size in healthy individuals: a narrative review.Lipids in health and disease · 2021Review
- Article
- The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders.Biomolecules · 2020Review
- Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease.Journal of lipid research · 2020Review
- Liver Metabolomics Reveals the Effect ofFrontiers in physiology · 2020Article
- Serum long-chain n-3 polyunsaturated fatty acids and aortic calcification in middle-aged men: The population-based cross-sectional ERA-JUMP study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019Article
- Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea.International journal of cardiology · 2018Article
- Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans.The British journal of nutrition · 2016Article
- Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men.International journal of cardiology · 2015Article
- Effect of PUFA-rich plant oil on risk factors of STZ-induced diabetes in Wistar rats.Redox report : communications in free radical research · 2014Article
- Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors.Atherosclerosis · 2014Article
- Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up.Lipids in health and disease · 2014Article
- Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study.European journal of clinical nutrition · 2013Article
- A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites.European heart journal. Cardiovascular Imaging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain.
objectiveWe aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL.
designWe conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids.
resultsSerum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA.
conclusionsAt the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at clinicaltrials.gov as NCT00069797.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.