ReviewProceedings. Biological sciences2010
In search of the chemical basis for MHC odourtypes.
Review in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Constructing an Olfactometer for Rodent Olfactory Behavior Studies.Journal of visualized experiments : JoVE · 2025Article
- No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.Proceedings. Biological sciences · 2024Article
- Human scent as a first-line defense against disease.Scientific reports · 2023Article
- How priming with body odors affects decision speeds in consumer behavior.Scientific reports · 2023Article
- A Review of Suggested Mechanisms of MHC Odor Signaling.Biology · 2022Review
- Feather chemicals contain information about the major histocompatibility complex in a highly scented seabird.Proceedings. Biological sciences · 2022Article
- House sparrows do not exhibit a preference for the scent of potential partners with different MHC-I diversity and genetic distances.PloS one · 2022Article
- Maternal chemosignals enhance infant-adult brain-to-brain synchrony.Science advances · 2021Article
- Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins.Viruses · 2021Article
- The specific biochemistry of human axilla odour formation viewed in an evolutionary context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Genetic variation at MHC class II loci influences both olfactory signals and scent discrimination in ring-tailed lemurs.BMC evolutionary biology · 2019Article
- Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).BMC biology · 2018Article
- Brain Injury Alters Volatile Metabolome.Chemical senses · 2016Article
- The search for human pheromones: the lost decades and the necessity of returning to first principles.Proceedings. Biological sciences · 2015Review
- Sexual selection and the evolutionary dynamics of the major histocompatibility complex.Proceedings. Biological sciences · 2014Article
- Of volatiles and peptides: in search for MHC-dependent olfactory signals in social communication.Cellular and molecular life sciences : CMLS · 2014Review
- Are mammal olfactory signals hiding right under our noses?Die Naturwissenschaften · 2013Review
- Review
- Mate choice for genetic compatibility in the house mouse.Ecology and evolution · 2013Article
- Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons.Nature communications · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice can discriminate between chemosignals of individuals based solely on genetic differences confined to the major histocompatibility complex (MHC). Two different sets of compounds have been suggested: volatile compounds and non-volatile peptides. Here, we focus on volatiles and review a number of publications that have identified MHC-regulated compounds in inbred laboratory mice. Surprisingly, there is little agreement among different studies as to the identity of these compounds. One recent approach to specifying MHC-regulated compounds is to study volatile urinary profiles in mouse strains with varying MHC types, genetic backgrounds and different diets. An unexpected finding from these studies is that the concentrations of numerous compounds are influenced by interactions among these variables. As a result, only a few compounds can be identified that are consistently regulated by MHC variation alone. Nevertheless, since trained animals are readily able to discriminate the MHC differences, it is apparent that chemical studies are somehow missing important information underlying mouse recognition of MHC odourtypes. To make progress in this area, we propose a focus on the search for behaviourally relevant odourants rather than a random search for volatiles that are regulated by MHC variation. Furthermore, there is a need to consider a 'combinatorial odour recognition' code whereby patterns of volatile metabolites (the basis for odours) specify MHC odourtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.