ReviewJournal of the Royal Society, Interface2010
Mechanosensitivity of ion channels based on protein-lipid interactions.
Review in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- MicroRNAs as Mediators of Mechanotransduction: from Fundamental Mechanisms to Therapeutic Applications.Cell biochemistry and biophysics · 2026Review
- Mechanosensitive aquaporins.Biophysical reviews · 2023Review
- Piezo1 Mechano-Activation Is Augmented by Resveratrol and Differs between Colorectal Cancer Cells of Primary and Metastatic Origin.Molecules (Basel, Switzerland) · 2022Article
- Roles of CCN2 as a mechano-sensing regulator of chondrocyte differentiation.The Japanese dental science review · 2020Review
- Effect of Pulsed Electromagnetic Fields on Human Mesenchymal Stem Cells Using 3D Magnetic Scaffolds.Bioelectromagnetics · 2020Article
- The mechanosensitive channel YbdG fromThe Journal of biological chemistry · 2019Article
- Molecular dynamics simulations of heterogeneous cell membranes in response to uniaxial membrane stretches at high loading rates.Scientific reports · 2017Article
- Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function.Physiology (Bethesda, Md.) · 2016Review
- Article
- Deformation of a micro-torque swimmer.Proceedings. Mathematical, physical, and engineering sciences · 2016Article
- Mechanical regulation of mesenchymal stem cell differentiation.Journal of anatomy · 2015Review
- Polycystins and mechanotransduction: From physiology to disease.World journal of experimental medicine · 2015Article
- Curvature-dependent protein-lipid bilayer interaction and cell mechanosensitivity.European biophysics journal : EBJ · 2015Article
- Plasma membrane mechanical stress activates TRPC5 channels.PloS one · 2015Article
- The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.Chemical reviews · 2014Review
- Polycystins and partners: proposed role in mechanosensitivity.The Journal of physiology · 2014Review
- Sensory TRP channel interactions with endogenous lipids and their biological outcomes.Molecules (Basel, Switzerland) · 2014Review
- Role of PKD2 in rheotaxis in Dictyostelium.PloS one · 2014Article
- Structural evidence for functional lipid interactions in the betaine transporter BetP.The EMBO journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion channels form a group of membrane proteins that pass ions through a pore beyond the energy barrier of the lipid bilayer. The structure of the transmembrane segment of membrane proteins is influenced by the charges and the hydrophobicity of the surrounding lipids and the pressure on its surface. A mechanosensitive channel is specifically designed to change its conformation in response to changes in the membrane pressure (tension). However, mechanosensitive channels are not the only group that is sensitive to the physical environment of the membrane: voltage-gated channels are also amenable to the lipid environment. In this article, we review the structure and gating mechanisms of the mechanosensitive channels and voltage-gated channels and discuss how their functions are affected by the physical properties of the lipid bilayer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.