Trial reportVaccine2010
Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
Trial report in Vaccine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Hepatitis B vaccination for reducing morbidity and mortality in persons with HIV infection.The Cochrane database of systematic reviews · 2014Pooled it
- Immunogenicity and safety of 1 vs 2 doses of quadrivalent meningococcal conjugate vaccine in youth infected with human immunodeficiency virus.The Journal of pediatrics · 2012Trial
- Review
- Hepatitis B Vaccination and Waning Hepatitis B Immunity in Persons Living with HIV.Current HIV/AIDS reports · 2019Review
- Health Considerations for HIV-Infected International Travelers.Current infectious disease reports · 2019Review
- Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection.Pathogens & immunity · 2017Article
- Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.PLoS pathogens · 2015Article
- Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya.BMC infectious diseases · 2015Article
- Hepatitis B and human immunodeficiency virus co-infection.World journal of gastroenterology · 2014Review
- Hepatitis B vaccine by intradermal route in non responder patients: an update.World journal of gastroenterology · 2014Review
- Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.Current opinion in virology · 2013Review
- Inadequate T follicular cell help impairs B cell immunity during HIV infection.Nature medicine · 2013Article
- Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1.The Lancet. Infectious diseases · 2012Review
- Persistence of Protective Hepatitis B Surface Antibody Titers after Successful Double-Dose Hepatitis B Virus Rescue Vaccination in HIV-Infected Patients.Gut and liver · 2012Article
- Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.The Journal of clinical investigation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.