ArticleBMC neurology2010
Evidence based guidelines for complex regional pain syndrome type 1.
Article in BMC neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07259382 (Neuro-Inflammation in Extremity Trauma), which is not on this map. Cited by 75 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study
Who cites it
75 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- A Systematic Critical Appraisal of Clinical Practice Guidelines for Non-Pharmacological Conservative Management of Complex Regional Pain Syndrome (CRPS) Using the AGREE-II Instrument.Journal of evaluation in clinical practice · 2026Pooled it
- Complex regional pain syndrome what is the outcome? - a systematic review of the course and impact of CRPS at 12 months from symptom onset and beyond.European journal of pain (London, England) · 2022Pooled it
- Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition.Pain medicine (Malden, Mass.) · 2022Guideline
- Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.The Cochrane database of systematic reviews · 2022Pooled it
- Usefulness of bone scintigraphy for the diagnosis of Complex Regional Pain Syndrome 1: A systematic review and Bayesian meta-analysis.PloS one · 2017Pooled it
- Local anaesthetic sympathetic blockade for complex regional pain syndrome.The Cochrane database of systematic reviews · 2016Pooled it
- Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.The Cochrane database of systematic reviews · 2016Pooled it
- Testing the validity of preventing chronic regional pain syndrome with vitamin C after distal radius fracture. [Corrected].The Journal of hand surgery · 2014Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Pain Exposure Physical Therapy versus conventional treatment in complex regional pain syndrome type 1-a cost-effectiveness analysis alongside a randomized controlled trial.Clinical rehabilitation · 2018Trial
- Trial
- Trial
- The effectiveness and cost evaluation of pain exposure physical therapy and conventional therapy in patients with complex regional pain syndrome type 1. Rationale and design of a randomized controlled trial.BMC musculoskeletal disorders · 2012Trial
- Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review.Pain practice : the official journal of World Institute of Pain · 2026Review
- Characterisation and non-pharmacological treatment of Complex Regional Pain Syndrome in under-18-year-olds: a scoping review.European journal of pediatrics · 2026Article
- Nationwide population based epidemiological characteristics of complex regional pain syndrome in South Korea.Scientific reports · 2026Article
- Sensory Processing Patterns in People With Complex Regional Pain Syndrome.OTJR : occupation, participation and health · 2025Article
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- Review
- Integrative approaches in spinal cord stimulation: Neuropathic pain management and motor recovery in spinal cord injury. A narrative review.Brain & spine · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I.
methodA multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according to their strength of evidence, published between 1980 to June 2005. Treatment recommendations based on the literature findings were formulated and formally approved by all Dutch professional associations involved in CRPS-I treatment.
resultsFor pain treatment, the WHO analgesic ladder is advised with the exception of strong opioids. For neuropathic pain, anticonvulsants and tricyclic antidepressants may be considered. For inflammatory symptoms, free-radical scavengers (dimethylsulphoxide or acetylcysteine) are advised. To promote peripheral blood flow, vasodilatory medication may be considered. Percutaneous sympathetic blockades may be used to increase blood flow in case vasodilatory medication has insufficient effect. To decrease functional limitations, standardised physiotherapy and occupational therapy are advised. To prevent the occurrence of CRPS-I after wrist fractures, vitamin C is recommended. Adequate perioperative analgesia, limitation of operating time, limited use of tourniquet, and use of regional anaesthetic techniques are recommended for secondary prevention of CRPS-I.
conclusionsBased on the literature identified and the extent of evidence found for therapeutic interventions for CRPS-I, we conclude that further research is needed into each of the therapeutic modalities discussed in the guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.