ArticleACS applied materials & interfaces2009
Near-infrared phosphorescent polymeric nanomicelles: efficient optical probes for tumor imaging and detection.
Article in ACS applied materials & interfaces, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Polymeric nanocarriers in drug delivery, bioimaging, and biosensing: advances and perspectives on nanomicelles, nanogels, and dendrimers.RSC advances · 2025Review
- Coverage- and Temperature-Dependent Rates of Metalation, Ring Fusion, and Polymerization of Benzoporphyrins on Cu(111).Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Crystallization induced room-temperature phosphorescence and chiral photoluminescence properties of phosphoramides.Chemical science · 2022Article
- Non-toxic near-infrared light-emitting diodes.iScience · 2021Review
- Recent Advances in Nanomicelles Delivery Systems.Nanomaterials (Basel, Switzerland) · 2020Review
- Quantitative Mapping of Liver Hypoxia in Living Mice Using Time-Resolved Wide-Field Phosphorescence Lifetime Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer.Chemical Society reviews · 2019Review
- An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging.Nanoscale · 2018Article
- BODIPY-Bacteriochlorin Energy Transfer Arrays: Toward Near-IR Emitters with Broadly Tunable, Multiple Absorption Bands.The Journal of organic chemistry · 2017Article
- Amphiphilic BODIPY-Hydroporphyrin Energy Transfer Arrays with Broadly Tunable Absorption and Deep Red/Near-Infrared Emission in Aqueous Micelles.The Journal of organic chemistry · 2017Article
- Multifunctional Phosphorescent Conjugated Polymer Dots for Hypoxia Imaging and Photodynamic Therapy of Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Long-wavelength analyte-sensitive luminescent probes and optical (bio)sensors.Methods and applications in fluorescence · 2015Article
- Biocompatible near-infrared fluorescent nanoparticles for macro and microscopic in vivo functional bioimaging.Biomedical optics express · 2014Article
- Quantification of the plasma clearance kinetics of a gadolinium-based contrast agent by photoinduced triplet harvesting.Analytical chemistry · 2012Article
- In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.Nanomedicine : nanotechnology, biology, and medicine · 2012Article
- In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer.Theranostics · 2012Article
- Gold nano-popcorn attached SWCNT hybrid nanomaterial for targeted diagnosis and photothermal therapy of human breast cancer cells.ACS applied materials & interfaces · 2011Article
- Article
- Magnetomotive molecular nanoprobes.Current medicinal chemistry · 2011Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report a formulation of near-infrared (near-IR) phosphorescent polymeric nanomicelles and their use for in vivo high-contrast optical imaging, targeting, and detection of tumors in small animals. Near-IR phosphorescent molecules of Pt(II)-tetraphenyltetranaphthoporphyrin (Pt(TPNP)) were found to maintain their near-IR phosphorescence properties when encapsulated into phospholipid nanomicelles. The prepared phosphorescent micelles are of approximately 100 nm size and are highly stable in aqueous suspensions. A large spectral separation between the Pt(TPNP) absorption, with a peak at approximately 700 nm, and its phosphorescence emission, with a peak at approximately 900 nm, allows a dramatic decrease in the level of background autofluorescence and scattered excitation light in the near-IR spectral range, where the signal from the phosphorescent probe is observed. In vivo animal imaging with subcutaneously xenografted tumor-bearing mice has resulted in high contrast optical images, indicating highly specific accumulation of the phosphorescent micelles into tumors. Using optical imaging with near-IR phosphorescent nanomicelles, detection of smaller, visually undetectable tumors has also been demonstrated.
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Registered trials
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