ArticlePhysical chemistry chemical physics : PCCP2010
Macromolecular crowding induces polypeptide compaction and decreases folding cooperativity.
Article in Physical chemistry chemical physics : PCCP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- MACRO-MOLECULAR CROWDING FAVORS WRITHE IN UNWOUND DNA.bioRxiv : the preprint server for biology · 2026Article
- Protein oxidation in crowded environments.The Biochemical journal · 2026Review
- Peptide-based drug design using generative AI.Chemical communications (Cambridge, England) · 2026Review
- Computational Approaches to Predict Protein-Protein Interactions in Crowded Cellular Environments.Chemical reviews · 2024Review
- Recent Advances in Protein Folding Pathway Prediction through Computational Methods.Current medicinal chemistry · 2024Review
- Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics.The journal of physical chemistry letters · 2023Article
- Entropy driven cooperativity effect in multi-site drug optimization targeting SARS-CoV-2 papain-like protease.Cellular and molecular life sciences : CMLS · 2023Article
- Structure and Dynamics of dsDNA in Cell-like Environments.Entropy (Basel, Switzerland) · 2022Review
- Crowding-induced protein destabilization in the absence of soft attractions.Biophysical journal · 2022Article
- Reaching new levels of realism in modeling biological macromolecules in cellular environments.Journal of molecular graphics & modelling · 2013Review
- Conformational sampling of peptides in the presence of protein crowders from AA/CG-multiscale simulations.The journal of physical chemistry. B · 2012Article
- Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant.Nucleic acids research · 2011Article
- The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics.PLoS computational biology · 2011Article
- Power-law dependence of the melting temperature of ubiquitin on the volume fraction of macromolecular crowders.The Journal of chemical physics · 2011Article
- Protein folding in the cell: challenges and progress.Current opinion in structural biology · 2011Review
- Article
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Authors and funding
2 authors.
Funding
Abstract
A cell's interior is comprised of macromolecules that can occupy up to 40% of its available volume. Such crowded environments can influence the stability of proteins and their rates of reaction. Using discrete molecular dynamics simulations, we investigate how both the size and number of neighboring crowding reagents affect the thermodynamic and folding properties of structurally diverse proteins. We find that crowding induces higher compaction of proteins. We also find that folding becomes less cooperative with the introduction of crowders into the system. The crowders may induce alternative non-native protein conformations, thus creating barriers for protein folding in highly crowded media.
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Registered trials
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