ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Anastomotic sealing by extracellular matrices (ECM) improves healing of colonic anastomoses in the critical early phase.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- External coating of colonic anastomoses: a systematic review.International journal of colorectal disease · 2012Pooled it
- Short-term outcomes of a novel anti-reflux biologic flap technique versus double flap technique after laparoscopic proximal gastrectomy: a retrospective cohort study.Surgical endoscopy · 2026Article
- Enhancement of gastrointestinal anastomosis healing via a small intestinal submucosa bio-patch: modulating IL-22 secretion by type 3 innate lymphoid cells and microbial structures.Frontiers in bioengineering and biotechnology · 2026Article
- Extracellular Matrix Hydrogel Reduces Anastomotic Leaks in a Rodent Model of Rectal Anastomosis.The Journal of surgical research · 2025Article
- Regeneration of the Gastrointestinal Tract After Using a Small Intestine Submucosa Patch-A Rat Model.Biomedicines · 2025Article
- New Technologies to Prevent Anastomotic Leak.Clinics in colon and rectal surgery · 2021Review
- Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- In vivo performance of a bilayer wrap to prevent abdominal adhesions.Acta biomaterialia · 2020Article
- Pluronic F127 blended polycaprolactone scaffolds via e-jetting for esophageal tissue engineering.Journal of materials science. Materials in medicine · 2018Article
- Impact of tissue adhesives on the prevention of anastomotic leakage of colonic anastomoses: an in vivo study.International journal of colorectal disease · 2017Article
- International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract.International journal of colorectal disease · 2016Article
- Colorectal anastomotic healing: why the biological processes that lead to anastomotic leakage should be revealed prior to conducting intervention studies.BMC gastroenterology · 2015Article
- Staple line/anastomotic reinforcement and other adjuncts: do they make a difference?Clinics in colon and rectal surgery · 2014Review
- Bovine pericardium patch wrapping intestinal anastomosis improves healing process and prevents leakage in a pig model.PloS one · 2014Article
- The effect of fibrin glue on the early healing phase of intestinal anastomoses in the rat.International journal of colorectal disease · 2012Article
- A highly elastic and adhesive gelatin tissue sealant for gastrointestinal surgery and colon anastomosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Extracellular matrices for gastrointestinal surgery: ex vivo testing and current applications.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracellular matrices have proven potential for in vivo tissue regeneration at gastrointestinal luminal organs. In this study, small intestinal submucosa (SIS) was tested as a sealant for colonic anastomoses in a rodent model.
methodsIn the rodent model, standard colonic anastomoses in the control group (CG; n = 30) and anastomoses sealed by omentum (n = 30) were compared to SIS-sealed anastomoses in the study group (SG; n = 30). After 4-, 30-, and 90-day macroscopic and microscopic healing, bursting pressure and anastomotic stricture rate were evaluated.
resultsThe rate of anastomotic dehiscence was 1/10 after 4 days and 0/10 after 30 and 90 days in all groups. In the SG, the bursting pressure was significantly increased after 4 days compared to CG (148 +/- 9 vs. 108 +/- 8 mmHg; p > 0.05). Histologically, after 4 days of neovascularization, fibroblast ingrowth and collagen deposition were significantly increased in SG compared to CG. After 30 days, nonsignificant differences were noted in all three parameters. Adhesion rate and anastomotic stricture rate were not significantly affected by SIS sealing after 4, 30, and 90 days.
conclusionEspecially in the critical phase of anastomotic healing up to day 4, anastomotic healing was improved by SIS sealing. SIS sealing did not cause long-term complications.
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