ArticleJournal of clinical monitoring and computing2010
The standard strong ion difference, standard total titratable base, and their relationship to the Boston compensation rules and the Van Slyke equation for extracellular fluid.
Article in Journal of clinical monitoring and computing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- On acid-base bilingualism.Intensive care medicine · 2025Article
- Understanding buffering of metabolic acidosis in critical illness.Intensive care medicine · 2024Article
- Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base.Theoretical biology & medical modelling · 2018Article
- Comprehensive diagnosis of whole-body acid-base and fluid-electrolyte disorders using a mathematical model and whole-body base excess.Journal of clinical monitoring and computing · 2015Article
- Partitioning standard base excess: a new approach.Journal of clinical monitoring and computing · 2011Article
- A comprehensive, computer-model-based approach for diagnosis and treatment of complex acid-base disorders in critically-ill patients.Journal of clinical monitoring and computing · 2011Article
- Strong ion reserve: a viewpoint on acid base equilibria and buffering.European journal of applied physiology · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
A general formalism for calculating physiological acid-base balance in multiple compartments is extended to the combined interstitial, plasma, and erythrocyte multicompartment system in humans using the Siggaard-Andersen approximation for interstitial fluid. The resulting equations for total titratable base and strong ion difference reproduce the experimental in vivo carbon dioxide titration curve as well as the experimental strong ion difference value of the interstitial, plasma, and erythrocyte system in normal man. The "Boston rules" for compensation in acute respiratory acidosis and alkalosis are then derived analytically from the model. The Van Slyke equation for the interstitial, plasma, and erythrocyte system is also derived and shown to approximate the Van Slyke equation for standard base excess.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.