ArticleClinical & experimental metastasis2010
Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis.
Article in Clinical & experimental metastasis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands.The Journal of nutritional biochemistry · 2016Article
- Multiscale analysis of the murine intestine for modeling human diseases.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.Molecular cancer research : MCR · 2015Article
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain.Genetics · 2012Article
- Epistatic Control of Mammary Cancer Susceptibility in Mice may Depend on the Dietary Environment.Hereditary genetics : current research · 2012Article
- Dairy milk fat augments paclitaxel therapy to suppress tumour metastasis in mice, and protects against the side-effects of chemotherapy.Clinical & experimental metastasis · 2011Article
- Map making in the 21st century: charting breast cancer susceptibility pathways in rodent models.Journal of mammary gland biology and neoplasia · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Among environmental factors, body composition and intake of specific dietary components like total fat are associated with increased incidence of breast cancer and metastasis. We previously showed that mice fed a high-fat diet have shorter mammary cancer latency, increased tumor growth and more pulmonary metastases than mice fed a standard diet. Subsequent genetic analysis identified several modifiers of metastatic mammary cancer along with widespread interactions between cancer modifiers and dietary fat. To elucidate diet-dependent genetic modifiers of mammary cancer and metastasis risk, global gene expression profiles and copy number alterations from mammary cancers were measured and expression quantitative trait loci (eQTL) identified. Functional candidate genes that colocalized with previously detected metastasis modifiers were identified. Additional analyses, such as eQTL by dietary fat interaction analysis, causality and database evaluations, helped to further refine the candidate loci to produce an enriched list of genes potentially involved in the pathogenesis of metastatic mammary cancer.
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Registered trials
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