Trial reportJournal of endocrinological investigation2010
Microalbuminuria is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 diabetes.
Trial report in Journal of endocrinological investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Endothelial Function in Pulmonary Arterial Hypertension: From Bench to Bedside.Journal of clinical medicine · 2024Review
- Overview of the Assessment of Endothelial Function in Humans.Frontiers in medicine · 2020Review
- Urinary Albumin Excretion and Vascular Function in Rheumatoid Arthritis.Journal of Korean medical science · 2016Article
- Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes.World journal of diabetes · 2015Review
- The prevalence, characteristics, and clinical significance of abnormal albuminuria in patients with hypertension.Scientific reports · 2014Article
- Microalbuminuria in untreated prehypertension and hypertension without diabetes.International journal of clinical and experimental medicine · 2014Article
- Association between urinary albumin excretion and coronary heart disease in black vs white adults.JAMA · 2013Article
- Correlation between microalbuminuria and cardiovascular events.International journal of clinical and experimental medicine · 2013Article
- Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertension.Circulation · 2012Article
- Gender difference in albuminuria and ischemic heart disease in type 2 diabetes.Clinical medicine & research · 2012Article
- Endothelial function in patients with slow coronary flow and normal coronary angiography.Clinics (Sao Paulo, Brazil) · 2012Article
- Albuminuria and Diabetic Retinopathy in Type 2 Diabetes Mellitus Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 12).Diabetology & metabolic syndrome · 2011Article
- Is the presence of microalbuminuria a relevant marker of kidney disease?Current hypertension reports · 2010Review
- Insulin therapy does not interfere with venous endothelial function evaluation in patients with type 2 diabetes mellitus.Clinics (Sao Paulo, Brazil) · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated.
aimTo study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria. MATERIAL AND
methodsWe evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively.
resultsPatients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007).
conclusionsBoth venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.
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