ArticleJournal of dental research2010
Altered fibroblast proliferation and apoptosis in diabetic gingival wounds.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Efficacy of Cellular Therapy for Diabetic Foot Ulcer: A Meta-Analysis of Randomized Controlled Clinical Trials.Cell transplantation · 2017Pooled it
- The role of adult tissue-derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine.International wound journal · 2016Pooled it
- Salivary NLRP3 inflammasome as a promising biomarker for palatal mucosa healing in diabetes mellitus: A pilot study.Journal of periodontology · 2026Article
- Unveiling the therapeutic role of 3D-cultured mesenchymal stem cells in diabetic foot ulcers through transcriptomic integration and fibroblast modulation.Molecular biology reports · 2026Article
- Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.Inflammation · 2026Article
- Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells.Scientific reports · 2025Article
- Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic Wounds.Aging cell · 2025Article
- Fibroblast Dysfunction and Immune Dysregulation Impair Palatal Wound Healing in Diabetic Rats.International dental journal · 2025Article
- The bidirectional association between diabetes and periodontitis, from basic to clinical.The Japanese dental science review · 2024Review
- Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing.Journal of nanobiotechnology · 2024Article
- The impact of metabolic disorders on management of periodontal health in children.Pediatric discovery · 2024Article
- Combined therapeutic strategy based on blocking the deleterious effects of AGEs for accelerating diabetic wound healing.Regenerative biomaterials · 2024Article
- Article
- Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients.Antioxidants (Basel, Switzerland) · 2023Review
- Addition of Resolvins D1 or E1 to Collagen Membranes Mitigates Their Resorption in Diabetic Rats.Journal of functional biomaterials · 2023Article
- Mechanisms of diabetic foot ulceration: A review.Journal of diabetes · 2023Review
- Silencing of topical proline hydroxylase domain 2 promotes the healing of rat diabetic wounds by phosphorylating AMPK.PloS one · 2023Article
- High Glucose Induces Late Differentiation and Death of Human Oral Keratinocytes.Current issues in molecular biology · 2022Article
- Diabetes complications and extracellular vesicle therapy.Reviews in endocrine & metabolic disorders · 2022Review
- Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation.Bioengineering (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with factors that decrease fibroblast numbers. Full-thickness wounds were created in the palatal gingiva of type 1 and type 2 diabetic and normoglycemic mice. Five days after wounding, diabetic mice had less epithelial wound coverage, less new connective tissue formation, and reduced fibroblast density (p < 0.05). This occurred with increased numbers of caspase-3- and TUNEL-positive fibroblasts, decreased fibroblast proliferation, increased nuclear translocation of the pro-apoptotic transcription factor FOXO1, and increased numbers of polymorphonuclear leukocytes, all of which were significant (p < 0.05). The results suggest that diabetes may decrease fibroblast numbers through increased apoptosis and reduced proliferation, both of which may be mediated through increased activation of FOXO1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.