ArticleThe Plant cell2010
F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.
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Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it, 251 citations in OpenAlex.
- Shades of green: untying the knots of green photoperception.Journal of experimental botany · 2020Pooled it
- Phosphate starvation induces root cell-type-specific transcriptional responses and alternative splicing.The New phytologist · 2026Article
- Flowering time regulation: a critical review focusing on FKF1 protein.Plant molecular biology · 2026Review
- Rice OsFKF1 Promotes Degradation of OsPRR37 for Short-Day Early Flowering.Rice (New York, N.Y.) · 2025Article
- Tomato in the spotlight: light regulation of whole-plant physiology.Journal of experimental botany · 2025Review
- Genetic architecture of a light-temperature coincidence detector.Nature communications · 2025Article
- The circadian clock module LgPRR7-LgFKF1 negatively regulates flowering time inHorticulture research · 2025Article
- Diurnal dynamics of different circadian transcription modules in Chinese pine needles and roots during dormancy induction.BMC plant biology · 2025Article
- Choosing which models best explain photoperiodic time measurement mechanisms in plants.Npj biological timing and sleep · 2025Review
- Nature's Master of Ceremony: TheNpj biological timing and sleep · 2025Article
- An Arabidopsis Cell Culture With Weak Circadian Rhythms Under Constant Light Compared With Constant Dark Can Be Rescued by ELF3.Plant direct · 2024Article
- HOS15-mediated turnover of PRR7 enhances freezing tolerance.The New phytologist · 2024Article
- Cold-induced degradation of core clock proteins implements temperature compensation in theScience advances · 2024Article
- Agrobacterium-mediated transformation of B. juncea reveals that BjuLKP2 functions in plant yellowing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- 40S Ribosomal protein S6 kinase integrates daylength perception and growth regulation in Arabidopsis thaliana.Plant physiology · 2024Article
- High expression of ethylene response factor BcERF98 delays the flowering time of non-heading Chinese cabbage.Planta · 2024Article
- HOS15-mediated turnover of PRR7 enhances freezing tolerance.bioRxiv : the preprint server for biology · 2024Article
- Comprehensive Genome-Wide Natural Variation and Expression Analysis of Tubby-like Proteins Gene Family inPlants (Basel, Switzerland) · 2024Article
- Functional Characterization of thePlants (Basel, Switzerland) · 2024Article
- The interplay between the circadian clock and abiotic stress responses mediated by ABF3 and CCA1/LHY.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
87 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Regulation of protein turnover mediated by ZEITLUPE (ZTL) constitutes an important mechanism of the circadian clock in Arabidopsis thaliana. Here, we report that FLAVIN BINDING, KELCH REPEAT, F-BOX1 (FKF1) and LOV KELCH PROTEIN2 (LKP2) play similar roles to ZTL in the circadian clock when ZTL is absent. In contrast with subtle circadian clock defects in fkf1, the clock in ztl fkf1 has a considerably longer period than in ztl. In ztl fkf1 lkp2, several clock parameters were even more severely affected than in ztl fkf1. Although LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) expression levels are lower in ztl than in the wild type, introducing both fkf1 and lkp2 mutations into the ztl mutant dramatically diminished LHY expression without further affecting CCA1 expression. This demonstrates different contributions of ZTL, FKF1, and LKP2 in the regulation of LHY and CCA1 expression. In addition, FKF1 and LKP2 also interacted with TIMING OF CAB EXPRESSION1 (TOC1) and PSEUDO-RESPONSE REGULATOR5 (PRR5), and both proteins were further stabilized in ztl fkf1 and ztl fkf1 lkp2 compared with in ztl. Our results indicate that ZTL, FKF1, and LKP2 together regulate TOC1 and PRR5 degradation and are major contributors to determining the period of circadian oscillation and enhancing robustness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.