ArticlePhysiological genomics2010
Identifying physiological origins of baroreflex dysfunction in salt-sensitive hypertension in the Dahl SS rat.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.Frontiers in pharmacology · 2024Article
- Acute and long-term effects of cannabinoids on hypertension and kidney injury.Scientific reports · 2022Article
- bp: Blood pressure analysis in R.PloS one · 2022Article
- Endothelin B receptors impair baroreflex function and increase blood pressure variability during high salt diet.Autonomic neuroscience : basic & clinical · 2021Article
- Using the Information Provided by Forbidden Ordinal Patterns in Permutation Entropy to Reinforce Time Series Discrimination Capabilities.Entropy (Basel, Switzerland) · 2020Article
- A model-based analysis of autonomic nervous function in response to the Valsalva maneuver.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Parameter subset selection techniques for problems in mathematical biology.Biological cybernetics · 2019Article
- Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation.Biological cybernetics · 2019Article
- Sex-specific long-term blood pressure regulation: Modeling and analysis.Computers in biology and medicine · 2019Article
- Computational model-based assessment of baroreflex function from response to Valsalva maneuver.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Expression of Proinflammatory Cytokines Is Upregulated in the Hypothalamic Paraventricular Nucleus of Dahl Salt-Sensitive Hypertensive Rats.Frontiers in physiology · 2018Article
- Modeling the differentiation of A- and C-type baroreceptor firing patterns.Journal of computational neuroscience · 2017Article
- Adaptive Sampling-Based Information Collection for Wireless Body Area Networks.Sensors (Basel, Switzerland) · 2016Article
- Effect of salt intake on beat-to-beat blood pressure nonlinear dynamics and entropy in salt-sensitive versus salt-protected rats.Physiological reports · 2016Article
- A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking.PloS one · 2016Article
- Dr Lewis Kitchener Dahl, the Dahl rats, and the "inconvenient truth" about the genetics of hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation.Mathematical biosciences · 2014Article
- Arterial stiffening provides sufficient explanation for primary hypertension.PLoS computational biology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat. However, neither the physiological mechanisms nor the genomic regions underlying the baroreflex dysfunction seen in this rat model are definitively known. Here, we have adopted a mathematical modeling approach to investigate the physiological and genetic origins of baroreflex dysfunction in the Dahl SS rat. We have developed a computational model of the overall baroreflex heart rate control system based on known physiological mechanisms to analyze telemetry-based blood pressure and heart rate data from two genetic strains of rat, the SS and consomic SS.13(BN), on low- and high-salt diets. With this approach, physiological parameters are estimated, unmeasured physiological variables related to the baroreflex control system are predicted, and differences in these quantities between the two strains of rat on low- and high-salt diets are detected. Specific findings include: a significant selective impairment in sympathetic gain with high-salt diet in SS rats and a protection from this impairment in SS.13(BN) rats, elevated sympathetic and parasympathetic offsets with high-salt diet in both strains, and an elevated sympathetic tone with high-salt diet in SS but not SS.13(BN) rats. In conclusion, we have associated several important physiological parameters of the baroreflex control system with chromosome 13 and have begun to identify possible physiological mechanisms underlying baroreflex impairment and hypertension in the Dahl SS rat that may be further explored in future experimental and modeling-based investigation.
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