ArticleEuropean journal of histochemistry : EJH2010
Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells.
Article in European journal of histochemistry : EJH, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of highly abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens.Frontiers in molecular biosciences · 2026Article
- Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrierWorld journal of gastroenterology · 2025Article
- Thymosin βCells · 2024Review
- Top-Down Proteomics of Human Saliva Discloses Significant Variations of the Protein Profile in Patients with Mastocytosis.Journal of proteome research · 2020Article
- Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.European journal of histochemistry : EJH · 2014Article
- Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract.European journal of histochemistry : EJH · 2013Article
- Density of mast cells and microvessels in minor salivary gland tumors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.European journal of histochemistry : EJH · 2013Article
- On the future contents of a small journal of histochemistry.European journal of histochemistry : EJH · 2012Article
- Identifying pathological biomarkers: histochemistry still ranks high in the omics era.European journal of histochemistry : EJH · 2011Article
- Expression pattern of thymosin beta 4 in the adult human liver.European journal of histochemistry : EJH · 2011Article
- Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects.European journal of histochemistry : EJH · 2010Article
- Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract.European journal of histochemistry : EJH · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells (MCs) are metachromatic cells that originate from multipotential hemopoietic stem cells in the bone marrow. Two distinct populations of MCs have been characterized: mucosal MCs are tryptase-positive while mast cells in skin contain tryptase and chymase. We now show that a sub-population of MCs is highly immunoreactive for thymosin beta4, as revealed by immunohistochemical analyses of normal skin, normal colon mucosa and salivary gland tumors. Four consecutive serial sections from each case were immunostained for thymosin beta4 (Tbeta4), chymase, tryptase and stained for toluidine blue. In skin biopsies, MCs showed a comparable immunoreactivity for Tbeta4, chymase and tryptase. In normal colon mucosa the vast majority of mucosal MCs expressed a strong cytoplasmic immunoreactivity for tryptase and for Tbeta4, in the absence of chymase reactivity. A robust expression of Tbeta4 was detected in tumor-infiltrating and peritumoral mast cells in salivary gland tumors and breast ductal infiltrating carcinomas. Tumor-infiltrating MCs also showed a strong immunoreactivity for chymase and tryptase. In this paper, we first demonstrate that normal dermal and mucosal mast cells exhibit strong expression of thymosin beta4, which could be considered a new marker for the identification of mast cells in skin biopsies as well as in human tumors. The possible relationship between the degree of Tbeta4 expression in tumor-infiltrating mast cells and tumor behaviour warrants further consideration in future investigations.
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