ArticleBiochemical and biophysical research communications2010
Neuropoietin activates STAT3 independent of LIFR activation in adipocytes.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Adipocyte Oncostatin Receptor Regulates Adipose Tissue Homeostasis and Inflammation.Frontiers in immunology · 2020Review
- Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells.Molecular medicine reports · 2019Article
- [Expression of miR-140-5p and prediction of its target gene in human mesenchymal stem cells during adipogenic differentiation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
- Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology.Orphanet journal of rare diseases · 2014Review
- Role of cytokine signaling during nervous system development.International journal of molecular sciences · 2013Review
- Identification of STAT target genes in adipocytes.JAK-STAT · 2013Review
- Article
- Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes.Immunogenetics · 2013Article
- Secretory TAT-peptide-mediated protein transduction of LIF receptor α-chain distal cytoplasmic motifs into human myeloid HL-60 cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Role of cardiotrophin-1 in obesity and insulin resistance.Adipocyte · 2012Article
- Emerging roles of JAK-STAT signaling pathways in adipocytes.Trends in endocrinology and metabolism: TEM · 2011Review
- Gp130 cytokines exert differential patterns of crosstalk in adipocytes both in vitro and in vivo.Obesity (Silver Spring, Md.) · 2011Article
- The gp130 receptor cytokine family: regulators of adipocyte development and function.Current pharmaceutical design · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neuropoietin (NP) is a member of the gp130 cytokine family that is closely related to cardiotrophin-1(CT-1) and shares functional and structural features with other family members, including ciliary neurotrophic factor (CNTF) and cardiotrophin-like cytokine (CLC). Studies have shown that NP can play a role in the development of the nervous system, as well as affect adipogenesis and fat cell function. However, the signaling mechanisms utilized by NP in adipocytes have not been examined. In our present studies, we demonstrate that NP-induced activation of STAT3 tyrosine phosphorylation is independent of leukemia inhibitory factor receptor (LIFR) phosphorylation and degradation. Although it is widely accepted that NP signals via the LIFR, our studies reveal that NP results in phosphorylation of gp130, but not LIFR. These observations suggest that the profound effects that NP has on adipocytes are not mediated via LIFR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.