ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2010
A naturally occurring outbreak of tuberculosis in a group of imported cynomolgus monkeys (Macaca fascicularis).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Natural outbreak ofJournal of toxicologic pathology · 2024Article
- Case report: Discovery of tuberculosis caused byFrontiers in veterinary science · 2024Article
- Intra-Palpebral Tuberculin Skin Test and Interferon Gamma Release Assay in Diagnosing Tuberculosis Due toPathogens (Basel, Switzerland) · 2022Article
- Article
- Tuberculosis detection in nonhuman primates is enhanced by use of testing algorithms that include an interferon-γ release assay.American journal of veterinary research · 2021Article
- Detection of tuberculosis in cynomolgus macaques (Macaca fascicularis) using a supplementary Monkey Interferon Gamma Releasing Assay (mIGRA).Scientific reports · 2020Article
- Revised recommendations for health monitoring of non-human primate colonies (2018): FELASA Working Group Report.Laboratory animals · 2019Article
- Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates.Journal of medical primatology · 2019Article
- A Novel Translational Model of Spinal Cord Injury in Nonhuman Primate.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- The tuberculin skin test in monkeys.Lab animal · 2016Article
- Disseminated Mycobacterium tuberculosis in imported Sooty Mangabey, Thailand.Emerging infectious diseases · 2015Article
- Modeling tuberculosis in nonhuman primates.Cold Spring Harbor perspectives in medicine · 2014Review
- From the mouths of monkeys: detection of Mycobacterium tuberculosis complex DNA from buccal swabs of synanthropic macaques.American journal of primatology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case report describes the diagnosis of tuberculosis (caused primarily by Mycobacterium bovis) in a group of newly imported Chinese origin cynomolgus monkeys. We also describe the use of sedation to enhance the accuracy of evaluation of the intrapalpebral tuberculin skin test using the mammalian old tuberculin reagent and report the first known diagnosis of Mycobacterium paraffinicum in a nonhuman primate. By 48 h after injection during the second tuberculin skin test, 6 of the 80 macaques had developed eyelid reactions ranging from mild (grade 1) to severe (grade 4). Given the range and severity of reactions, we suspected an outbreak of tuberculosis in the group. Because of the nature of the reactions, we sedated the animals at the 72-h evaluation to more closely observe and then palpate the injected eyelid. Evaluation of unsedated animals revealed 22 with a reaction to mammalian old tuberculin. We confirmed these 22 cases and identified an additional 11 animals with reactions when the monkeys were sedated. Mycobacterial culture of tissue from 6 macaques with reactions confirmed M. bovis in 3 animals. In addition, 1 of these 3 animals was culture-positive for both M. bovis and M. paraffinicum, and another was culture-positive for M. avium complex only. The addition of sedation to facilitate visual inspection and then palpation of the injected eyelid of these macaques increased the accuracy of evaluation and understanding of the number and severity of reactions to tuberculin skin testing.
Indexed as
Identifiers
20353699PMC2846012W2156050848What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.