ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2010
Endotoxin, coliform, and dust levels in various types of rodent bedding.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Complex Substrates and Bedding for Environmental Enhancement and Research: Or, the Nature of Primates.American journal of primatology · 2026Review
- Beyond Comfort: A Review of the Critical Role of Bedding Selection in Rodent Welfare, Microenvironment, and Research Reproducibility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Enhancing Rodent Welfare, Cost Savings, and Efficiency: Implementation and Review of Data-Driven Improvements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Guidelines for diet-induced models of cardiometabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2025Review
- Analysis of Individually Ventilated Cage (IVC) Microenvironments During 21-d Cage Change Frequency for Mice Using Two Different Bedding Types.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A Review of the Effects of Some Extrinsic Factors on Mice Used in Research.Comparative medicine · 2023Review
- Effect of Husbandry Practices on the Fecal Microbiota of C57BL/6J Breeding Colonies Housed in 2 Different Barrier Facilities in the Same Institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Effect of Bedding Substrates on Blood Glucose and Body Weight in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Identification of Rodent Husbandry Refinement Opportunities through Benchmarking and Collaboration.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- What's wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Article
- Effects of Compressed Paper Bedding on Mouse Breeding Performance and Recognition of Animal Health Concerns.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Comparative Effects of 1/4-inch and 1/8-inch Corncob Bedding on Cage Ammonia Levels, Behavior, and Respiratory Pathology of Male C57BL/6 and 129S1/Svlm Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Compressed Paper as an Alternative to Corn Cob Bedding in Mouse (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Review
- Bedding-generated particulate matter: implications for rodent studies.Inhalation toxicology · 2019Article
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut.Scientific reports · 2018Article
- Article
- PCR Testing of IVC Filter Tops as a Method for Detecting Murine Pinworms and Fur Mites.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Endotoxins in grain dust, household dust, and animal bedding may induce respiratory symptoms in rodents and humans. We assayed the endotoxin, coliform, and dust levels in 20 types of rodent bedding. Endotoxin concentrations were measured by using a commercial test kit, coliform counts were determined by using conventional microbiologic procedures, and dust content was evaluated by using a rotating-tapping shaker. Paper bedding types contained significantly less endotoxin than did other bedding types; the highest levels of endotoxin were detected in hardwood and corncob beddings. The range of endotoxin content for each bedding type was: corncob bedding, 1913 to 4504 endotoxin units per gram (EU/g); hardwood bedding, 3121 to 5401 EU/g; corncob-paper mixed bedding, 1586 to 2416 EU/g; and paper bedding, less than 5 to 105 EU/g. Coliform counts varied from less than 10 to 7591 cfu/g in corncob beddings, 90 to 4010 cfu/g in corncob-paper mixed beddings, less than 10 to 137 cfu/g in hardwood beddings, and less than 10 cfu/g in paper beddings. Average dust content was less than 0.15% in all commercial bedding types. We conclude that paper bedding is the optimal bedding type for conducting LPS inhalation studies and that rodent bedding containing high levels of endotoxin may alter the results of respiratory and immunologic studies in rodents.
Indexed as
Identifiers
20353693PMC2846006W1570602560What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.