ArticleBMC evolutionary biology2010
High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern Europe.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Article
- Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality?Frontiers in physiology · 2021Article
- Molecular inferences about the genus Hypostomus Lacépède, 1803 (Siluriformes: Loricariidae): a review.Molecular biology reports · 2020Review
- The Pastoral Origin of Semiotically Functional Tonal Organization of Music.Frontiers in psychology · 2020Article
- The genomic ancestry of the Scandinavian Battle Axe Culture people and their relation to the broader Corded Ware horizon.Proceedings. Biological sciences · 2019Article
- Determination of Milk Products in Ceramic Vessels of Corded Ware Culture from a Late Eneolithic Burial.Molecules (Basel, Switzerland) · 2018Article
- Earliest expansion of animal husbandry beyond the Mediterranean zone in the sixth millennium BC.Scientific reports · 2017Article
- Evolutionary Patterns and Processes: Lessons from Ancient DNA.Systematic biology · 2017Review
- Methods and models for unravelling human evolutionary history.Nature reviews. Genetics · 2015Review
- Humans as cucinivores: comparisons with other species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- The Interrelationships between Lactose Intolerance and the Modern Dairy Industry: Global Perspectives in Evolutional and Historical Backgrounds.Nutrients · 2015Review
- The utility of ancient human DNA for improving allele age estimates, with implications for demographic models and tests of natural selection.Journal of human evolution · 2015Article
- Article
- Prevalence of self-reported stomach symptoms after consuming milk among indigenous Sami and non-Sami in Northern- and Mid-Norway - the SAMINOR study.International journal of circumpolar health · 2015Article
- Toward a new history and geography of human genes informed by ancient DNA.Trends in genetics : TIG · 2014Review
- Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe.PloS one · 2014Article
- Ancestry of modern Europeans: contributions of ancient DNA.Cellular and molecular life sciences : CMLS · 2013Review
- Low prevalence of lactase persistence in Neolithic South-West Europe.European journal of human genetics : EJHG · 2012Article
- Distinguishing between selective sweeps from standing variation and from a de novo mutation.PLoS genetics · 2012Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenes and culture are believed to interact, but it has been difficult to find direct evidence for the process. One candidate example that has been put forward is lactase persistence in adulthood, i.e. the ability to continue digesting the milk sugar lactose after childhood, facilitating the consumption of raw milk. This genetic trait is believed to have evolved within a short time period and to be related with the emergence of sedentary agriculture.
resultsHere we investigate the frequency of an allele (-13910*T) associated with lactase persistence in a Neolithic Scandinavian population. From the 14 individuals originally examined, 10 yielded reliable results. We find that the T allele frequency was very low (5%) in this Middle Neolithic hunter-gatherer population, and that the frequency is dramatically different from the extant Swedish population (74%).
conclusionsWe conclude that this difference in frequency could not have arisen by genetic drift and is either due to selection or, more likely, replacement of hunter-gatherer populations by sedentary agriculturalists.
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