ArticleBMC medical genetics2010
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis.Current rheumatology reports · 2021Review
- The Impacts ofInternational journal of general medicine · 2021Article
- The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Article
- IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Impact of IL1R1 and IL1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case-control study.Molecular genetics & genomic medicine · 2019Article
- Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1.Bioscience reports · 2018Article
- Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.Nature reviews. Rheumatology · 2018Review
- Association of genetic polymorphisms inOncotarget · 2017Article
- Perceived cognitive function for breast cancer survivors: association of genetic and behaviorally related variables for inflammation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- IL1R1 gene polymorphisms are associated with knee osteoarthritis risk in the Chinese Han population.Oncotarget · 2017Article
- A Brief History of IL-1 and IL-1 Ra in Rheumatology.Frontiers in pharmacology · 2017Article
- Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors.Cellular & molecular immunology · 2015Article
- Occupational and genetic risk factors for osteoarthritis: a review.Work (Reading, Mass.) · 2015Review
- Gene Expression Profiling in Peripheral Blood Cells and Synovial Membranes of Patients with Psoriatic Arthritis.PloS one · 2015Article
- Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.Molecular medicine (Cambridge, Mass.) · 2014Article
- A cytochrome P450 regulates a domestication trait in cultivated tomato.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort.Osteoarthritis and cartilage · 2013Article
- Combined effect of cytokine gene polymorphisms on end-stage knee osteoarthritis from Chinese Han population.Rheumatology international · 2012Article
- Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.The journal of pain · 2012Article
- IL1RL1 gene variants and nasopharyngeal IL1RL-a levels are associated with severe RSV bronchiolitis: a multicenter cohort study.PloS one · 2012Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn search for genes predisposing to osteoarthritis (OA), several genome wide scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families.
methodsWe genotyped 32 single nucleotide polymorphisms (SNPs) in this 470 kb region comprising six genes belonging to the interleukin 1 superfamily and monitored for association with individual SNPs and SNP haplotypes among severe familial hand OA cases (material extended from our previous linkage study; n = 134), unrelated end-stage bilateral primary knee OA cases (n = 113), and population based controls (n = 436).
resultsFour SNPs in the IL1R1 gene, mapping to a 125 kb LD block, provided evidence for association with hand OA in family-based and case-control analysis, the strongest association being with SNP rs2287047 (p-value = 0.0009).
conclusionsThis study demonstrates an association between severe hand OA and IL1R1 gene. This gene represents a highly relevant biological candidate since it encodes protein that is a known modulator of inflammatory processes associated with joint destruction and resides within a locus providing consistent evidence for linkage to hand OA. As the observed association did not fully explain the linkage obtained in the previous study, it is plausible that also other variants in this genome region predispose to hand OA.
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