ReviewActa physiologica (Oxford, England)2010
Control of muscle blood flow during exercise: local factors and integrative mechanisms.
Review in Acta physiologica (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- Effects of different exercise modalities and doses on arterial stiffness in individuals with overweight and obesity: a systematic review and Bayesian dose-response meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Arterio-venous metabolite and electrolyte responses to low-load training with and without blood flow restriction versus high-load training to failure.European journal of applied physiology · 2026Trial
- Intradialytic Exercise: Effects on Arterial Stiffness and Gait Speed in Patients Undergoing Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Effects of dynamic, isometric and combined resistance training on blood pressure and its mechanisms in hypertensive men.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Trial
- Partial-body cryotherapy (-135°C) and cold-water immersion (10°C) after muscle damage in females.Scandinavian journal of medicine & science in sports · 2020Trial
- Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.The Journal of physiology · 2019Trial
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Effects of a pre-workout supplement on hyperemia following leg extension resistance exercise to failure with different resistance loads.Journal of the International Society of Sports Nutrition · 2017Trial
- Post-exercise home-based hot-bathing with/without light exercise: effects on physiological adaptations to short-term high-intensity resistance training in healthy young men.European journal of applied physiology · 2026Article
- Managing Vaginismus with Assisted Dilatation Multidisciplinary Protocol - Retrospective Cohort Study from Indonesia's Largest Dedicated Centre.International journal of women's health · 2026Article
- Examination of post-exercise microvascular reactivity in healthy adults.European journal of applied physiology · 2026Article
- Microvascular arteriolar reactivity in response to skeletal muscle contractions in female and male hamsters.Physiological reports · 2025Article
- Hypohydration augments the acute increase in urinary biomarkers of kidney injury following the 100-mile Western States Endurance Run.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cardiorespiratory Fitness as a Determinant of Arterial Elasticity in Response to Exercise: Evidence from a Study of Young Athletes and Healthy Controls.Acta Cardiologica Sinica · 2025Article
- Effect of pre-exercise dietary nitrate on skeletal muscle blood flow in a rat model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity.American journal of physiology. Endocrinology and metabolism · 2025Article
- Effects of autoregulated and non-autoregulated blood flow restriction on vastus medialis oblique responses during low-load resistance exercise.Frontiers in sports and active living · 2025Article
- Evaluation of Peripheral Circulatory Changes Following Hydrotherapy and Controlled Physical Training in Patients with Atherosclerotic Lower Limb Ischemia.Life (Basel, Switzerland) · 2024Article
- Review
- The Effect of Oral Adenosine Triphosphate (ATP) Supplementation on Anaerobic Exercise in Healthy Resistance-Trained Individuals: A Systematic Review and Meta-Analysis.Sports (Basel, Switzerland) · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Understanding the control mechanisms of blood flow within the vasculature of skeletal muscle is clearly fascinating from a theoretical point of view due to the extremely tight coupling of tissue oxygen demands and blood flow. It also has practical implications as impairment of muscle blood flow and its prevention/reversal by exercise training has a major impact on widespread diseases such as hypertension and diabetes. Here we analyse the role of mediators generated by skeletal muscle activity on smooth muscle relaxation in resistance vessels in vitro and in vivo. We summarize their cellular mechanisms of action and their relative roles in exercise hyperaemia with regard to early and late responses. We also discuss the consequences of interactions among mediators with regard to identifying their functional significance. We focus on (potential) mechanisms integrating the action of the mediators and their effects among the cells of the intact arteriolar wall. This integration occurs both locally, partly due to myoendothelial communication, and axially along the vascular tree, thus enabling the local responses to be manifest along an entire functional vessel path. Though the concept of signal integration is intriguing, its specific role on the control of exercise hyperaemia and the consequences of its modulation under physiological and pathophysiological conditions still await additional analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.