ArticleBJOG : an international journal of obstetrics and gynaecology2010
The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women.
Article in BJOG : an international journal of obstetrics and gynaecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Effect of micronutrient supplements on low-risk pregnancies in high-income countries: a systematic quantitative literature review.Public health nutrition · 2020Pooled it
- Folic Acid and Risk of Preterm Birth: A Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands.BMC pregnancy and childbirth · 2014Trial
- The association between maternal multivitamin intake and premature birth.Scientific reports · 2026Article
- Maternal Methyl-Group Donor Intake and Neonatal Birth Size in Singleton IVF Pregnancies.Nutrients · 2026Article
- Article
- Article
- Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2021Article
- Article
- Nutritional-Related Predictors of Preterm Birth in North Shewa Hospitals, Central Ethiopia: A Case-Control Study.Pediatric health, medicine and therapeutics · 2021Article
- High starchy food intake may increase the risk of adverse pregnancy outcomes: a nested case-control study in the Shaanxi province of Northwestern China.BMC pregnancy and childbirth · 2019Article
- Perspective: An Extension of the STROBE Statement for Observational Studies in Nutritional Epidemiology (STROBE-nut): Explanation and Elaboration.Advances in nutrition (Bethesda, Md.) · 2017Article
- Association of influenza vaccination during pregnancy with birth outcomes in Nicaragua.Vaccine · 2017Observational
- Folic acid supplementation, dietary folate intake and risk of preterm birth in China.European journal of nutrition · 2016Article
- Use of a web-based dietary assessment tool in early pregnancy.Irish journal of medical science · 2016Article
- The Effect of Iron Deficiency on Osmotic Sensitivity of Red Blood Cells from Neonatal Rats and Their Mothers.The Journal of membrane biology · 2015Article
- Maternal iron status in early pregnancy and birth outcomes: insights from the Baby's Vascular health and Iron in Pregnancy study.The British journal of nutrition · 2015Article
- Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study.BMC pregnancy and childbirth · 2014Observational
- Folic acid supplementation in pregnancy and implications in health and disease.Journal of biomedical science · 2014Review
- Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.Epigenetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the relationship between dietary supplement use during pregnancy and birth outcomes.
designA prospective birth cohort.
settingLeeds, UK. SAMPLE: One thousand two hundred and seventy-four pregnant women aged 18-45 years.
methodsDietary supplement intake was ascertained using three questionnaires for the first, second and third trimesters. Dietary intake was reported in a 24-hour dietary recall administered by a research midwife at 8-12 weeks of gestation. Information on delivery details and antenatal pregnancy complications was obtained from the hospital maternity records.
main outcome measuresBirthweight, birth centile and preterm birth.
resultsReported dietary supplement use declined from 82% of women in the first trimester of pregnancy to 22% in the second trimester and 33% in the third trimester. Folic acid was the most commonly reported supplement taken. Taking any type of daily supplement during any trimester was not significantly associated with size at birth taking into account known relevant confounders. Women taking multivitamin-mineral supplements in the third trimester were more likely to experience preterm birth (adjusted OR = 3.4, 95% CI 1.2, 9.6, P = 0.02).
conclusionsRegular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, it appears to be associated with preterm birth if taken daily in the third trimester. The mechanism for this is unclear and our study's findings need confirming by other cohorts and/or trials in developed countries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.