ReviewPediatric nephrology (Berlin, Germany)2010
A conceptual framework for the molecular pathogenesis of progressive kidney disease.
Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Changes in Kidney Function Among Malaysian Adolescents and Its Determinants.Kidney international reports · 2023Article
- Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Renal Tubular Cell-Derived Extracellular Vesicles Accelerate the Recovery of Established Renal Ischemia Reperfusion Injury.Journal of the American Society of Nephrology : JASN · 2017Article
- The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction.American journal of physiology. Renal physiology · 2016Review
- Remnant nephron physiology and the progression of chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.American journal of physiology. Renal physiology · 2013Article
- Hypertension and chronic kidney disease progression: why the suboptimal outcomes?The American journal of medicine · 2012Review
- Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.Kidney international · 2012Article
- Tubulointerstitial injury and the progression of chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2012Review
- Urinary levels of TGF β-1 and of cytokines in patients with prenatally detected nephrouropathies.Pediatric nephrology (Berlin, Germany) · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of information being generated on this topic threatens to overwhelm our efforts to understand progression in chronic kidney disease or to derive rational strategies to treat it. Here, a conceptual framework is offered for organizing and considering these data. Disease is initiated by an injury that evokes a tissue-specific cellular response. Subsequent structural repair may be effective, or the new structure may be sufficiently changed that it requires an adaptive physiological response. If this adaptation is not successful, subsequent cycles of misdirected repair or maladaptation may lead to progressive nephron loss. To illustrate how this framework can be used to organize our approach to disease pathogenesis, the role of cytokines in proteinuria and progressive glomerular disease is discussed. Finally, this theoretical framework is reconsidered to examine its implications for the diagnosis and treatment of clinical conditions. Application of this schema could have significant relevance to both research inquiry and clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.