Evidence map›Paper›PMID 20352449›Full record

ArticleParasitology research2010

Lymphocytes and not IFN-gamma mediate expression of iNOS by intestinal epithelium in murine cryptosporidiosis.

Shila K Nordone, Jody L Gookin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Cryptosporidiosis-an overview.Journal of biomedical research · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shila K NordoneNorth Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
Jody L Gookin
North Carolina State University · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
NO&Epithelial Repair in CryptosporidiosisK08DK002868 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI GOOKIN, JODY · 2002 to 2006
$634k
Role of iNOS and CAT-2 in defense against CP infectionR03DK070883 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI GOOKIN, JODY · 2005 to 2006
$144k
NIDDK NIH HHS K08 DK002868NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R03 DK070883
6 · The paper itself

Abstract

We hypothesized that unrecognized differences in epithelial expression of inducible nitric oxide synthase (iNOS), resulting from engineered immunodeficiency, could explain the contradictory findings of prior studies regarding the importance of nitric oxide (NO) in murine models of Cryptosporidium parvum infection. Severe combined immunodeficient mice (SCID) failed to constitutively or inducibly express epithelial iNOS or increase NO synthesis in response to C. parvum infection. In contrast, mice lacking IFN-gamma alone induced both epithelial iNOS expression and NO synthesis in response to infection. Accordingly, lymphocytes mediate epithelial expression of iNOS and NO synthesis independent of IFN-gamma in response to C. parvum infection. These findings in large part explain the contradictory conclusions of prior studies regarding the role of iNOS in C. parvum infection.

Indexed as

AnimalsCryptosporidiosisCryptosporidium parvumFemaleInterferon-gammaIntestinal MucosaLymphocytesMiceMice, Inbred BALB CMice, KnockoutMice, SCIDNitric Oxide Synthase Type IIInterferon-gammaNitric Oxide Synthase Type IINos2 protein, mouse

Identifiers

PMID20352449
PMCPMC3684203
OpenAlexW2038648282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.