ArticleClinical research in cardiology : official journal of the German Cardiac Society2010
Strain and strain rate echocardiography for evaluation of right ventricular dysfunction in patients with idiopathic pulmonary arterial hypertension.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Right Ventricular Strain by Echocardiography: Current Clinical Applications and Future Directions for Mechanics Assessment of the Forgotten Ventricle.Journal of personalized medicine · 2025Review
- Role of functional echocardiographic parameters in the diagnosis of bronchopulmonary dysplasia-associated pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Pulmonary hypertension in the developing world: Local registries, challenges, and ways to move forward.Global cardiology science & practice · 2020Article
- Two-dimensional speckle tracking echocardiography assessed right ventricular function and exercise capacity in pre-capillary pulmonary hypertension.The international journal of cardiovascular imaging · 2019Article
- Diagnosis and Pathophysiological Mechanisms of Group 3 Hypoxia-Induced Pulmonary Hypertension.Current treatment options in cardiovascular medicine · 2019Review
- Fast assessment of long axis strain with standard cardiovascular magnetic resonance: a validation study of a novel parameter with reference values.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Multiplane two-dimensional strain echocardiography for segmental analysis of right ventricular mechanics: new-RV study.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Non-invasive quantification of right ventricular systolic function by echocardiography: a new semi-automated approach.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Mid-term differences in right ventricular function in patients with congenital diaphragmatic hernia compared with controls.World journal of pediatrics : WJP · 2012Article
- Review of MR elastography applications and recent developments.Journal of magnetic resonance imaging : JMRI · 2012Review
- Today's and tomorrow's imaging and circulating biomarkers for pulmonary arterial hypertension.Cellular and molecular life sciences : CMLS · 2012Review
- Intimal sarcoma of the pulmonary artery with unusual findings: a case report.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Rapid assessment of longitudinal systolic left ventricular function using speckle tracking of the mitral annulus.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Tricuspid annular plane systolic excursion and right ventricular ejection fraction in pediatric and adolescent patients with tetralogy of Fallot, patients with atrial septal defect, and age-matched normal subjects.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Non-invasive imaging of global and regional cardiac function in pulmonary hypertension.Pulmonary circulationArticle
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Authors and funding
6 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Optimizing the non-invasive imaging of right ventricular (RV) function is of increasing interest for therapy monitoring and risk stratification in patients with idiopathic pulmonary hypertension (IPAH). Therefore, this study evaluated strain and strain rate echocardiography as a tool for comprehensive assessment of RV function and disease severity in IPAH patients. In 30 IPAH patients [WHO functional classes II-IV; mean pulmonary artery pressure (mPAP) 48.8 +/- 12.5 mmHg; pulmonary vascular resistance (PVR) 7.9 +/- 5.3 Wood units] and in 10 matched healthy control subjects' two-dimensional echocardiography, 6-MWD and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were obtained. In IPAH patients when compared with controls, RV systolic strain (-18.8 +/- 4.3 vs. -34.5 +/- 3.8%, p = 0.0016) and strain rate (-1.6 +/- 0.6 vs. -2.7 +/- 0.5 s(-1), p = 0.018) were significantly altered and correlated significantly with elevated NT-proBNP levels (r = 0.73 and r = 0.62; p < 0.001, respectively) and reduced 6-MWD (r = -0.76 and r = -0.81; p < 0.001). In IPAH patients, reduced strain correlated with both mPAP (r = 0.61, p = 0.01 for strain; and r = 0.55, p = 0.04 for strain rate, respectively), and PVR (r = 0.84, p < 0.001 for strain; and r = 0.67, p < 0.001 for strain rate, respectively). This study gives first comprehensive evidence that strain echocardiography allows accurate non-invasive assessment of RV function and disease severity in patients with IPAH.
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