Trial reportPsychopharmacology2010
Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study.
Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Does impulsivity change rate dependently following stimulant administration? A translational selective review and re-analysis.Psychopharmacology · 2016Pooled it
- A multi-pronged investigation of option generation using depression, PET and modafinil.Brain : a journal of neurology · 2022Trial
- Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.Psychopharmacology · 2021Trial
- Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study.Psychopharmacology · 2019Trial
- Processing Speed Predicts Behavioral Treatment Outcomes in Children with Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Type.Journal of abnormal child psychology · 2018Trial
- Single-session transcranial direct current stimulation induces enduring enhancement of visual processing speed in patients with major depression.European archives of psychiatry and clinical neuroscience · 2017Trial
- Examining the efficacy of d-cycloserine to augment therapeutic learning in depression.Contemporary clinical trials · 2016Trial
- A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.Brain : a journal of neurology · 2013Trial
- Working memory capacity predicts effects of methylphenidate on reversal learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Acute effects of modafinil on brain resting state networks in young healthy subjects.PloS one · 2013Trial
- Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.Neuropharmacology · 2013Trial
- A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor.Journal of neuro-oncology · 2012Trial
- Prompt but inefficient: nicotine differentially modulates discrete components of attention.Psychopharmacology · 2011Trial
- Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Effects of acute modafinil on cognition in trichotillomania.Psychopharmacology · 2010Trial
- Article
- Change in striatal functional connectivity networks across 2 years due to stimulant exposure in childhood ADHD: results from the ABCD sample.Translational psychiatry · 2024Observational
- Change in Striatal Functional Connectivity Networks Across Two Years Due to Stimulant Exposure in Childhood ADHD: Results from the ABCD Sample.medRxiv : the preprint server for health sciences · 2024Article
- Persistent neurocognitive deficits in cognitively impaired survivors of sepsis are explained by reductions in working memory capacity.Frontiers in psychology · 2024Article
- Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task: differential effects of dopaminergic and noradrenergic manipulations.Psychopharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionTheory of visual attention (TVA; Bundesen 1990) whole report tasks allow the independent measurement of visual perceptual processing speed and visual short-term memory (vSTM) storage capacity, unconfounded by motor speed. This study investigates how cognitive enhancing effects of psychostimulants depend on baseline performance and individual plasma levels. MATERIALS AND
methodsEighteen healthy volunteers (aged 20-35 years) received single oral doses of either 40 mg methylphenidate, 400 mg modafinil or placebo in a counterbalanced, double-blind crossover design. A whole report of visually presented letter arrays was performed 2.5-3.5 h after drug administration, and blood samples for plasma level analysis were taken.
resultsMethylphenidate and modafinil both enhanced perceptual processing speed in participants with low baseline (placebo) performance. These improvements correlated with subjective alertness. Furthermore, we observed differential plasma level-dependent effects of methylphenidate in lower and higher performing participants: higher plasma levels led to a greater improvement in low-performing participants and to decreasing improvement in high-performing participants. Modafinil enhanced visual short-term memory storage capacity in low-performing participants.
conclusionsThis is the first pharmacological investigation demonstrating the usefulness of a TVA task for high-resolution and repeated cognitive parameter estimation after cognitive-enhancing medication. Our results confirm previous findings of attentional capacity improvements in low performers and extend the baseline dependency model to methylphenidate. Plasma level-dependent effects of psychostimulants can be modelled on an inverted U-shaped dose-response relationship, which is highly relevant to predict cognitive enhancing and detrimental effects of psychostimulants in patients with cognitive deficits (e.g., attention deficit hyperactivity disorder) and healthy volunteers (e.g., self-medicating academics).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.