Evidence map›Paper›PMID 20351820›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2009

Using SNOMED CT in combination with MedDRA for reporting signal detection and adverse drug reactions reporting.

Olivier Bodenreider

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Evaluating MedDRA-to-ICD terminology mappings.BMC medical informatics and decision making · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Effect of vocabulary mapping for conditions on phenotype cohorts.Journal of the American Medical Informatics Association : JAMIA · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Standardizing adverse drug event reporting data.Journal of biomedical semantics · 2014
    Article
  11. Article
  12. Leveraging standards to support patient-centric interdisciplinary plans of care.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2011
    Article
  13. Article
  14. Drug safety surveillance using de-identified EMR and claims data: issues and challenges.Journal of the American Medical Informatics Association : JAMIA
    Article
  15. Evaluating standard terminologies for encoding allergy information.Journal of the American Medical Informatics Association : JAMIA
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Olivier BodenreiderNational Library of Medicine, Bethesda, Maryland, USA. olivier@nlm.nih.gov

Funding

National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7M
Intramural NIH HHS Z99 LM999999
6 · The paper itself

Abstract

objectiveTo investigate the feasibility of using SNOMED CT as an entry point for coding adverse drug reactions and map them automatically to MedDRA for reporting purposes and interoperability with legacy repositories.

methodsOn the one hand, we attempt to map SNOMED CT concepts to MedDRA concepts through the UMLS, using synonymy and explicit mapping relations. On the other, we compute the set of all fine-grained concepts that can be reached from concepts having a mapping to MedDRA.

results58% of the Preferred Terms in MedDRA have a mapping to SNOMED CT. Through the descendants in SNOMED CT, 108,305 additional SNOMED CT concepts can be linked to MedDRA.

conclusionsFine-grained SNOMED CT concepts can be mapped automatically to MedDRA. This approach has the potential to enable the collection of adverse events related to drugs directly from clinical repositories. The quality of the mapping needs to be evaluated.

Indexed as

Adverse Drug Reaction Reporting SystemsSystematized Nomenclature of MedicineUnified Medical Language SystemVocabulary, ControlledDrug-Related Side Effects and Adverse ReactionsFeasibility StudiesSystems IntegrationTerminology as Topic

Identifiers

PMID20351820
PMCPMC2815504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.