ReviewMolecular psychiatry2011
Big ideas for small brains: what can psychiatry learn from worms, flies, bees and fish?
Review in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The effects of Arabian jasmine on zebrafish behavior depends on strain, sex, and personality.PloS one · 2025Article
- Screening selected medicinal plants for potential anxiolytic activity using an in vivo zebrafish model.Psychopharmacology · 2020Article
- Framework for integrating animal welfare into life cycle sustainability assessment.The international journal of life cycle assessment · 2018Article
- Crayfish Self-Administer Amphetamine in a Spatially Contingent Task.Frontiers in physiology · 2018Article
- Gene networks show associations with seed region connectivity.Human brain mapping · 2017Article
- Transient Dysregulation of Dopamine Signaling in a DevelopingFrontiers in psychiatry · 2017Article
- Unlocking the treasure trove: from genes to schizophrenia biology.Schizophrenia bulletin · 2014Review
- Teratological effects of a panel of sixty water-soluble toxicants on zebrafish development.Zebrafish · 2014Article
- Zebrafish as an emerging model for studying complex brain disorders.Trends in pharmacological sciences · 2014Review
- Cocaine affects foraging behaviour and biogenic amine modulated behavioural reflexes in honey bees.PeerJ · 2014Article
- Schizophrenia at a genetics crossroads: where to now?Schizophrenia bulletin · 2013Article
- Review
- Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia.Translational psychiatry · 2013Article
- A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target.PLoS genetics · 2013Article
- The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants.Molecular psychiatry · 2013Review
- Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models.Translational psychiatry · 2012Review
- Transient knockdown of tyrosine hydroxylase during development has persistent effects on behaviour in adult zebrafish (Danio rerio).PloS one · 2012Article
- Modeling anxiety using adult zebrafish: a conceptual review.Neuropharmacology · 2012Review
- Article
- New perspectives on rodent models of advanced paternal age: relevance to autism.Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the research community has accepted the value of rodent models as informative research platforms, there is less awareness of the utility of other small vertebrate and invertebrate animal models. Neuroscience is increasingly turning to smaller, non-rodent models to understand mechanisms related to neuropsychiatric disorders. Although they can never replace clinical research, there is much to be learnt from 'small brains'. In particular, these species can offer flexible genetic 'tool kits' that can be used to explore the expression and function of candidate genes in different brain regions. Very small animals also offer efficiencies with respect to high-throughput screening programs. This review provides a concise overview of the utility of models based on worm, fruit fly, honeybee and zebrafish. Although these species may have small brains, they offer the neuropsychiatric research community opportunities to explore some of the most important research questions in our field.
Indexed as
Identifiers
20351718What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.