ArticleProceedings of the National Academy of Sciences of the United States of America2010
Cell pole-specific activation of a critical bacterial cell cycle kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Synchronized Swarmers and Sticky Stalks: Caulobacter crescentus as a Model for Bacterial Cell Biology.Journal of bacteriology · 2023Review
- CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance toFrontiers in cellular and infection microbiology · 2022Article
- A pseudokinase version of the histidine kinase ChrS promotes high heme tolerance ofFrontiers in microbiology · 2022Article
- Glutathione Synthesis Regulated by CtrA ProtectsFrontiers in microbiology · 2022Article
- Activation of a signaling pathway by the physical translocation of a chromosome.Developmental cell · 2021Article
- Regulation of Bacterial Cell Cycle Progression by Redundant Phosphatases.Journal of bacteriology · 2020Article
- The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.Journal of the Royal Society, Interface · 2020Article
- Integrative and quantitative view of the CtrA regulatory network in a stalked budding bacterium.PLoS genetics · 2020Article
- Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus.Nature microbiology · 2020Article
- Integration of cell cycle signals by multi-PAS domain kinases.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Protease ClpXP and the PAS Domain Protein DivL Regulate CtrA and Gene Transfer Agent Production in Rhodobacter capsulatus.Applied and environmental microbiology · 2018Article
- A Kinase-Phosphatase Switch Transduces Environmental Information into a Bacterial Cell Cycle Circuit.PLoS genetics · 2016Article
- Caulobacter PopZ forms an intrinsically disordered hub in organizing bacterial cell poles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An intracellular compass spatially coordinates cell cycle modules in Caulobacter crescentus.Current opinion in microbiology · 2016Review
- A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues.Nature communications · 2016Article
- Cell-Size Homeostasis and the Incremental Rule in a Bacterial Pathogen.Biophysical journal · 2015Article
- Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models.PLoS computational biology · 2015Article
- Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein.Nature communications · 2015Article
- Comparative analysis of wolbachia genomes reveals streamlining and divergence of minimalist two-component systems.G3 (Bethesda, Md.) · 2015Article
- Cell fate regulation governed by a repurposed bacterial histidine kinase.PLoS biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Caulobacter crescentus integrates phospho-signaling pathways and transcription factor regulatory cascades to drive the cell cycle. Despite the essential role of the CckA histidine kinase in the control of cell cycle events, the factors that signal its activation at a specific time in the cell cycle have remained elusive. A conditional genetic screen for CckA mislocalization mutants, using automated fluorescence microscopy and an image processing platform, revealed that the essential DivL protein kinase promotes CckA localization, autophosphorylation, and activity at the new cell pole. The transient accumulation of DivL at the new cell pole, but not its kinase activity, is required for the localization and activation of CckA. Because DivL and CckA accumulate at the same cell pole after the initiation of DNA replication and were found to interact in vivo, we propose that DivL recruits CckA to the pole, thereby promoting its autophosphorylation and activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.