ArticleProceedings of the National Academy of Sciences of the United States of America2010
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Heterodimerization with signaling-inert TLR8b converts TLR8a from proviral to antiviral sensor in Ctenopharyngodon idella.Cell communication and signaling : CCS · 2026Article
- Glucose-regulated protein 94 (Grp94/gp96) in viral pathogenesis: Insights into its role and therapeutic potentials.European journal of medicinal chemistry · 2025Review
- Tumor Temperature: Friend or Foe of Virus-Based Cancer Immunotherapy.Biomedicines · 2022Review
- Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19.Microbiology spectrum · 2021Article
- gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections.Journal of virology · 2020Article
- Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan.PloS one · 2020Article
- Review
- TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis.PLoS neglected tropical diseases · 2019Article
- Chaperoning theViruses · 2018Review
- The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.International journal of molecular sciences · 2018Review
- Cell entry of a host-targeting protein of oomycetes requires gp96.Nature communications · 2018Article
- Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.The Journal of biological chemistry · 2017Article
- Evolutionary decay and the prospects for long-term disease intervention using engineered insect vectors.Evolution, medicine, and public health · 2015Review
- Characterization of resistance to rhabdovirus and retrovirus infection in a human myeloid cell line.PloS one · 2015Article
- GP96 interacts with HHV-6 during viral entry and directs it for cellular degradation.PloS one · 2014Article
- Characteristics of oncolytic vesicular stomatitis virus displaying tumor-targeting ligands.Journal of virology · 2013Article
- Understanding and altering cell tropism of vesicular stomatitis virus.Virus research · 2013Review
- LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Improving promiscuous mammalian cell entry by the baculovirus Autographa californica multiple nuclear polyhedrosis virus.Bioscience reports · 2012Article
- LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.Molecular cell · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The envelope glycoprotein of vesicular stomatitis virus (VSV-G) enables viral entry into hosts as distant as insects and vertebrates. Because of its ability to support infection of most, if not all, human cell types VSV-G is used in viral vectors for gene therapy. However, neither the receptor nor any specific host factor for VSV-G has been identified. Here we demonstrate that infection with VSV and innate immunity via Toll-like receptors (TLRs) require a shared component, the endoplasmic reticulum chaperone gp96. Cells without gp96 or with catalytically inactive gp96 do not bind VSV-G. The ubiquitous expression of gp96 is therefore essential for the remarkably broad tropism of VSV-G. Cells deficient in gp96 also lack functional TLRs, which suggests that pathogen-driven pressure for TLR-mediated immunity maintains the broad host range of VSV-G by positively selecting for the ubiquitous expression of gp96.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.