ArticleProceedings of the National Academy of Sciences of the United States of America2010
Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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Who cites it
126 citing papers in PubMed, 237 citations in OpenAlex.
- A shared low-frequency oscillatory rhythm abnormality in resting and sensory gating in schizophrenia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2012Trial
- Astrocyte-Mediated Plasticity: Multi-Scale Mechanisms Linking Synaptic Dynamics to Learning and Memory.Cells · 2025Review
- Auditory stimulation at individual gamma frequency enhances cognitive performance.Scientific reports · 2025Article
- Theta-nested gamma oscillations balance prediction and vigilance in spatial navigation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome.medRxiv : the preprint server for health sciences · 2025Article
- Cross-Frequency Couplings Reveal Mice Visual Cortex Selectivity to Grating Orientations.Brain and behavior · 2025Article
- Article
- An exploration of the editing cut as an articulator in film through frequency domain analysis of spectator EEGs.Frontiers in neuroscience · 2025Article
- The classification of absence seizures using power-to-power cross-frequency coupling analysis with a deep learning network.Frontiers in neuroinformatics · 2025Article
- Neural circuits for the adaptive regulation of fear and extinction memory.Frontiers in behavioral neuroscience · 2024Review
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Hippocampal inactivation during rearing on hind legs impairs spatial memory.Scientific reports · 2023Article
- Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis.Aging and disease · 2023Review
- Hippocampal oscillatory dynamics in freely behaving rats during exploration of social and non-social stimuli.Cognitive neurodynamics · 2023Article
- Neuroprosthetics: from sensorimotor to cognitive disorders.Communications biology · 2023Review
- Gamma music: a new acoustic stimulus for gamma-frequency auditory steady-state response.Frontiers in human neuroscience · 2023Article
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- State space methods for phase amplitude coupling analysis.Scientific reports · 2022Article
- Cognitive control, interference inhibition, and ordering of information during working memory in younger and older healthy adults.GeroScience · 2022Article
66 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Episodic memory requires the hippocampus, which is thought to bind cortical inputs into conjunctive codes. Local field potentials (LFPs) reflect dendritic and synaptic oscillations whose temporal structure may coordinate cellular mechanisms of plasticity and memory. We now report that single-trial spatial memory performance in rats was predicted by the power comodulation of theta (4-10 Hz) and low gamma (30-50 Hz) rhythms in the hippocampus. Theta-gamma comodulation (TGC) was prominent during successful memory retrieval but was weak when memory failed or was unavailable during spatial exploration in sample trials. Muscimol infusion into medial septum reduced the probability of TGC and successful memory retrieval. In contrast, patterned electrical stimulation of the fimbria-fornix increased TGC in amnestic animals and partially rescued memory performance in the water maze. The results suggest that TGC accompanies memory retrieval in the hippocampus and that patterned brain stimulation may inform therapeutic strategies for cognitive disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.