ArticleProceedings of the National Academy of Sciences of the United States of America2010
Transcriptional activation in the context of repression mediated by archaeal histones.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Chromatin and gene regulation in archaea.Molecular microbiology · 2025Review
- Archaeal histone-based chromatin structures regulate transcription elongation rates.Communications biology · 2024Article
- DNA-bridging by an archaeal histone variant via a unique tetramerisation interface.Communications biology · 2023Article
- Role of the histone tails in histone octamer transfer.Nucleic acids research · 2023Article
- Specific DNA binding of archaeal histones HMfA and HMfB.Frontiers in microbiology · 2023Article
- An archaeal histone-like protein regulates gene expression in response to salt stress.Nucleic acids research · 2021Article
- Extended Archaeal Histone-Based Chromatin Structure Regulates Global Gene Expression inFrontiers in microbiology · 2021Article
- Archaeal transcription.Transcription · 2020Review
- Chromatinization ofeLife · 2019Article
- The Role of Archaeal Chromatin in Transcription.Journal of molecular biology · 2019Review
- Old cogs, new tricks: the evolution of gene expression in a chromatin context.Nature reviews. Genetics · 2019Review
- Structure and function of archaeal histones.PLoS genetics · 2018Review
- Transcription Regulation in Archaea.Journal of bacteriology · 2016Review
- Article
- The interplay between nucleoid organization and transcription in archaeal genomes.Nature reviews. Microbiology · 2015Review
- Archaeal nucleosome positioning in vivo and in vitro is directed by primary sequence motifs.BMC genomics · 2013Article
- An archaeal histone is required for transformation of Thermococcus kodakarensis.Journal of bacteriology · 2012Article
- Archaeal RNA polymerase and transcription regulation.Critical reviews in biochemistry and molecular biology · 2011Review
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many archaea (including all the methanogens, nearly all euryarchaeotes, and some crenarchaeotes) use histones as components of the chromatin that compacts their genomes. The archaeal histones are homo- and heterodimers that pair on DNA to form tetrasomes (as the eukaryotic histones H3 and H4 do). The resulting DNA packaging is known to interfere with assembly of the archaeal transcription apparatus at promoters; the ability of transcriptional activation to function in repressive archaeal chromatin has not yet been explored in vitro. Using four of the Methanocaldococcus jannaschii (Mja) histones, we have examined activation of the model Mja rb2 transcription unit by the Mja transcriptional activator Ptr2 in this simplified-chromatin context. Using hydroxyl radical footprinting, we find that the Ptr2-specific rb2 upstream activating site is a preferred histone-localizing site that nucleates histone: DNA-binding radiating from the rb2 promoter. Nevertheless, Ptr2 competes effectively with histones for access to the rb2 promoter and most potently activates transcription in vitro at histone concentrations that extensively coat DNA and essentially silence basal transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.