ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity.Journal of clinical medicine · 2021Review
- IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung.Translational research : the journal of laboratory and clinical medicine · 2020Article
- Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection.Scientific reports · 2020Article
- Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.Nature communications · 2020Article
- STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- ADAP Promotes Degranulation and Migration of NK Cells Primed DuringFrontiers in immunology · 2019Article
- NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.Frontiers in immunology · 2019Article
- Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.Central-European journal of immunology · 2019Article
- The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.PLoS pathogens · 2018Article
- A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection.Cell reports · 2018Article
- Natural Killer Cells: Development, Maturation, and Clinical Utilization.Frontiers in immunology · 2018Review
- AImmunoHorizons · 2017Article
- Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection.PLoS pathogens · 2017Article
- Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci.Frontiers in microbiology · 2017Article
- Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.Immunobiology · 2016Review
- Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection.PLoS pathogens · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms for NK cell activation during infection by intracellular bacterial pathogens are not clearly defined. To dissect how Listeria monocytogenes infection elicits NK cell activation, we evaluated the requirements for activation of naive splenic NK cells by infected bone marrow-derived dendritic cells (BMDCs). We found that NK cell activation in this setting required infection of BMDCs by live wild type bacteria. NK cells were not activated when BMDCs were infected with a live hemolysin deficient (Deltahly) strain. Neutralization of IL-12, TNF-alpha, or caspase-1 each dramatically reduced NK cell IFN-gamma production in response to live wt L. monocytogenes infection. Addition of recombinant IL-18, but not IL-1beta, reversed the effects of caspase-1 inhibition. Recombinant IL-18 also restored NK cell activation by BMDCs infected with Deltahly L. monocytogenes, which produced IL-12 but not IL-18. IL-18 acted on NK cells because MyD88 expression was required in responding NK cells, but not infected BMDC. However, secreted cytokines were not sufficient for activation of naive NK cells by infected BMDCs. Rather, NK cell activation additionally required contact between infected BMDCs and NK cells. These data suggest that the activation of NK cells during L. monocytogenes infection requires both secreted cytokines and ligation of NK activating receptors during direct contact with infected DCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.