ArticleMolecular and cellular biology2010
skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
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- Tyrosine catabolites influence SKN-1 signaling in a model of Type I Tyrosinemia.microPublication biology · 2022Article
- Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity iniScience · 2020Article
- The ω-3 fatty acid α-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARα and oxidation to oxylipins.Aging cell · 2017Article
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- Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.Nature medicine · 2016Article
- The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.Current genomics · 2014Article
- The ubiquitin proteasome system in Caenorhabditis elegans and its regulation.Redox biology · 2014Review
- TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.PLoS genetics · 2013Article
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- Improved vectors for selection of transgenic Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans.Developmental biology · 2013Article
- Glucose delays age-dependent proteotoxicity.Aging cell · 2012Article
- DAF-12 regulates a connected network of genes to ensure robust developmental decisions.PLoS genetics · 2011Article
- Life and destruction: ubiquitin-mediated proteolysis in aging and longevity.F1000 biology reports · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Maintenance of a stable, properly folded, and catalytically active proteome is a major challenge to organisms in the face of multiple internal and external stresses which damage proteins and lead to protein misfolding. Here we show that internal metabolic stress produced by reactive intermediates resulting from tyrosine degradation triggers the expression of the aip-1 gene, which is critical in responses to the environmental toxin arsenic and the clearance of unstable polyglutamine and Abeta proteins. aip-1 acts via binding to the proteosome and enhancing proteosomal function. We find that full induction of aip-1 depends on the oxidative-stress-responsive skn-1 transcription factor but significant induction still occurs without skn-1. Importantly, activation of skn-1 with wdr-23(RNAi), which dramatically induces the expression of other skn-1 target genes, produces a minimal increase in aip-1 expression. This suggests that the previously demonstrated specificity in aip-1/AIRAP induction could reflect the actions of multiple synergistic activators, such as the heat shock factor homolog hsf-1, which we also find is required for full induction. These may be triggered by proteosome dysfunction, as we find that this event links the multiple inducers of aip-1. Together, our results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.