ArticleMolecular and cellular biology2010
Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Connecting the DOTs on Cell Identity.Frontiers in cell and developmental biology · 2022Review
- Maternal DOT1L is dispensable for mouse development.Scientific reports · 2020Article
- Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.Genome biology · 2015Article
- Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.eLife · 2014Article
- Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing.Nucleic acids research · 2014Article
- De novo DNA methylation in the male germ line occurs by default but is excluded at sites of H3K4 methylation.Cell reports · 2013Article
- Identification of imprinting regulators at the Meg3 differentially methylated region.Genomics · 2012Article
- Epigenetics of drug abuse: predisposition or response.Pharmacogenomics · 2012Review
- A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci.Epigenetics & chromatin · 2012Article
- Chromatin immunoprecipitation to characterize the epigenetic profiles of imprinted domains.Methods in molecular biology (Clifton, N.J.) · 2012Article
- More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain.Frontiers in genetics · 2012Article
- A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression.The Journal of biological chemistry · 2011Article
- Article
- Chromosome-wide analysis of parental allele-specific chromatin and DNA methylation.Molecular and cellular biology · 2011Article
- Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Epigenetics & chromatin · 2011Article
- MIRA-SNuPE, a quantitative, multiplex method for measuring allele-specific DNA methylation.Epigenetics · 2011Article
- Article
- Coordinated allele-specific histone acetylation at the differentially methylated regions of imprinted genes.Nucleic acids research · 2010Article
- CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.PLoS genetics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Imprinted gene expression corresponds to parental allele-specific DNA CpG methylation and chromatin composition. Histone tail covalent modifications have been extensively studied, but it is not known whether modifications in the histone globular domains can also discriminate between the parental alleles. Using multiplex chromatin immunoprecipitation-single nucleotide primer extension (ChIP-SNuPE) assays, we measured the allele-specific enrichment of H3K79 methylation and H4K91 acetylation along the H19/Igf2 imprinted domain. Whereas H3K79me1, H3K79me2, and H4K91ac displayed a paternal-specific enrichment at the paternally expressed Igf2 locus, H3K79me3 was paternally biased at the maternally expressed H19 locus, including the paternally methylated imprinting control region (ICR). We found that these allele-specific differences depended on CTCF binding in the maternal ICR allele. We analyzed an additional 11 differentially methylated regions (DMRs) and found that, in general, H3K79me3 was associated with the CpG-methylated alleles, whereas H3K79me1, H3K79me2, and H4K91ac enrichment was specific to the unmethylated alleles. Our data suggest that allele-specific differences in the globular histone domains may constitute a layer of the "histone code" at imprinted genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.