ArticleInfection and immunity2010
Biological characterization of Chlamydia trachomatis plasticity zone MACPF domain family protein CT153.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genomic insights into local-scale evolution of ocularMicrobial genomics · 2024Article
- Genomic analysis of 61 Chlamydia psittaci strains reveals extensive divergence associated with host preference.BMC genomics · 2023Article
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- Host cell death during infection with Chlamydia: a double-edged sword.FEMS microbiology reviews · 2021Review
- Comparative Genome Analysis of 33Pathogens (Basel, Switzerland) · 2020Article
- An Ancient Molecular Arms Race:Frontiers in immunology · 2020Review
- Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease.BMC genomics · 2018Article
- Article
- Culture-independent metagenomics supports discovery of uncultivable bacteria within the genus Chlamydia.Scientific reports · 2017Article
- Targeting phospholipase D in cancer, infection and neurodegenerative disorders.Nature reviews. Drug discovery · 2017Review
- Mutational Analysis of the Chlamydia muridarum Plasticity Zone.Infection and immunity · 2015Article
- Trachoma and Ocular Chlamydial Infection in the Era of Genomics.Mediators of inflammation · 2015Review
- An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins.Molecular microbiology · 2014Article
- In silico scrutiny of genes revealing phylogenetic congruence with clinical prevalence or tropism properties of Chlamydia trachomatis strains.G3 (Bethesda, Md.) · 2014Article
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- Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous system.BMC microbiology · 2014Article
- Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections.Frontiers in cellular and infection microbiology · 2014Review
- Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections.Immunologic research · 2013Review
- Article
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Authors and funding
5 authors.
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Abstract
Chlamydia trachomatis strains are obligate intracellular human pathogens that share near genomic synteny but have distinct infection and disease organotropisms. The genetic basis for differences in the pathogen-host relationship among chlamydial strains is linked to a variable region of chlamydial genomes, termed the plasticity zone (PZ). Two groups of PZ-encoded proteins, the membrane attack complex/perforin (MACPF) domain protein (CT153) and members of the phospholipase D-like (PLD) family, are related to proteins that modify membranes and lipids, but the functions of CT153 and the PZ PLDs (pzPLDs) are unknown. Here, we show that full-length CT153 (p91) was present in the elementary bodies (EBs) of 15 C. trachomatis reference strains. CT153 underwent a rapid infection-dependent proteolytic cleavage into polypeptides of 57 and 41 kDa that was independent of de novo chlamydial protein synthesis. Following productive infection, p91 was expressed during the mid-developmental cycle and was similarly processed into p57 and p41 fragments. Infected-cell fractionation studies showed that insoluble fractions contained p91, p57, and p41, whereas only p91 was found in the soluble fraction, indicating that unprocessed CT153 may be secreted. Finally, CT153 localized to a distinct population of reticulate bodies, some of which were in contact with the inclusion membrane.
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