ArticleThe Journal of physiology2010
Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.PLoS biology · 2025Article
- Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.Pharmacological research · 2025Article
- Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net.Brain structure & function · 2021Review
- Article
- Autaptic Cultures: Methods and Applications.Frontiers in synaptic neuroscience · 2020Article
- Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations.PLoS biology · 2019Article
- Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators.Nature communications · 2019Article
- Autapses enhance bursting and coincidence detection in neocortical pyramidal cells.Nature communications · 2018Article
- Symmetries Constrain Dynamics in a Family of Balanced Neural Networks.Journal of mathematical neuroscience · 2017Article
- Wiring Specificity and Synaptic Diversity in the Mouse Lateral Central Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Presynaptic cholinergic neuromodulation alters the temporal dynamics of short-term depression at parvalbumin-positive basket cell synapses from juvenile CA1 mouse hippocampus.Journal of neurophysiology · 2015Article
- A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses.Mathematical biosciences · 2014Article
- Autaptic connections and synaptic depression constrain and promote gamma oscillations.PloS one · 2014Article
- GABAB Receptors Regulate Extrasynaptic GABAA Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Assortment of GABAergic plasticity in the cortical interneuron melting pot.Neural plasticity · 2011Review
- Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.PLoS biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neocortical fast-spiking (FS) basket cells form dense autaptic connections that provide inhibitory GABAergic feedback after each action potential. It has been suggested that these autaptic connections are used because synaptic communication is sensitive to neuromodulation, unlike the voltage-sensitive potassium channels in FS cells. Here we show that layer V FS interneurons form autaptic connections that are largely perisomatic, and without perturbing intracellular Cl(-) homeostasis, that perisomatic GABAergic currents have a reversal potential of 78 +/- 4 mV. Using variance-mean analysis, we demonstrate that autaptic connections have a mean of 14 release sites (range 4-26) with a quantal amplitude of 101 +/- 16 pA and a probability of release of 0.64 (V(command) = 70 mV, [Ca(2+)](o) = 2 mM, [Mg(2+)](o) = 1 mM). We found that autaptic GABA release is sensitive to GABA(B) and muscarinic acetylcholine receptors, but not a range of other classical neuromodulators. Our results indicate that GABA transporters do not regulate FS interneuron autapses, yet autaptically released GABA does not act at GABA(B) or extrasynaptic GABA(A) receptors. This research confirms that the autaptic connections of FS cells are indeed susceptible to modulation, though only via specific GABAergic and cholinergic mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.